Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glucokinase regulatory protein | competitive inhibitor of GCK activity, fructose 6-phoshate and fructose 1-phosphate enhance or reduce glucokinase regulatory protein-mediated inhibition, respectively. P446L-glucokinase regulatory protein has reduced regulation by physiological concentrations of fructose 6-phoshate, resulting indirectly in increased glucokinase activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | very low expression | Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | not expressed in skeletal muscle and kidney | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
pancreatic islet | highest expression in islet cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCK | - |
Homo sapiens |
glucokinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | glucokinase regulates glucose storage and disposal in the liver, altered glucokinase regulation in liver enhances glycolytic flux, promoting hepatic glucose metabolism and elevating concentrations of malonyl-CoA, a substrate for de novo lipogenesis | Homo sapiens |