Literature summary for 2.7.1.1 extracted from

Nishimura, T.; Iino, T.; Mitsuya, M.; Bamba, M.; Watanabe, H.; Tsukahara, D.; Kamata, K.; Sasaki, K.; Ohyama, S.; Hosaka, H.; Futamura, M.; Nagata, Y.; Eiki, J.
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators (2009), Bioorg. Med. Chem. Lett., 19, 1357-1360.

Activating Compound

Activating Compound	Comment	Organism
2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide	-	Rattus norvegicus
2-amino-4-chloro-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-(1H-imidazol-2-ylsulfanyl)-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-(2-fluorophenoxy)-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-(2-methoxyphenoxy)-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-(3-fluorophenoxy)-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-(4-fluorophenoxy)-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-(ethylsulfanyl)-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-chloro-N-(1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-chloro-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-ethoxy-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(1,2,4-thiadiazol-5-yl)benzamide	-	Rattus norvegicus
2-amino-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]benzamide	-	Rattus norvegicus
2-amino-5-[2-[methyl(methylidene)oxido-l6-sulfanyl]phenoxy]-N-(4-methyl-1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-N-(1,3-thiazol-2-yl)benzamide	-	Rattus norvegicus
2-amino-N-(3-methyl-1,2,4-thiadiazol-5-yl)-5-(phenylsulfanyl)benzamide	-	Rattus norvegicus
2-amino-N-(3-methyl-1,2,4-thiadiazol-5-yl)-5-(pyridin-2-ylsulfanyl)benzamide	-	Rattus norvegicus
2-amino-N-(3-methyl-1,2,4-thiadiazol-5-yl)-5-(pyridin-3-ylsulfanyl)benzamide	-	Rattus norvegicus
2-amino-N-(3-methyl-1,2,4-thiadiazol-5-yl)-5-(pyridin-4-ylsulfanyl)benzamide	-	Rattus norvegicus
2-amino-N-(3-methyl-1,2,4-thiadiazol-5-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide	-	Rattus norvegicus
2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-(4H-1,2,4-triazol-3-ylsulfanyl)benzamide	-	Rattus norvegicus
2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-(phenylsulfanyl)benzamide	-	Rattus norvegicus
2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-(pyridin-2-ylsulfanyl)benzamide	-	Rattus norvegicus
2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide	-	Rattus norvegicus
2-amino-N-(4-methylthiazol-2-yl)-5-phenoxybenzamide	-	Rattus norvegicus
2-amino-N-(5-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide	-	Rattus norvegicus
2-amino-N-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide	-	Rattus norvegicus
ethyl 2-[([2-amino-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]phenyl]carbonyl)amino]-1,3-thiazole-4-carboxylate	-	Rattus norvegicus
N-(4-methyl-1,3-thiazol-2-yl)-3-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide	-	Rattus norvegicus
N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-2-nitrobenzamide	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-glucose	-	Rattus norvegicus	ADP + D-glucose 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glucokinase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus