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Literature summary for 2.7.1.1 extracted from

  • Zhang, X.; Liang, W.; Mao, Y.; Li, H.; Yang, Y.; Tan, H.
    Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice (2009), Biomed. Pharmacother., 63, 180-186.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alloxan alloxan treatment (100 mg/kg) leads to an 81% reduction in glucokinase immunoreactivity and a greater than 90% reduction in glucokinase enzymatic activity in the liver Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
Mus musculus ADP + D-glucose 6-phosphate
-
?

Synonyms

Synonyms Comment Organism
glucokinase
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus the glucokinase protein levels in liver of alloxan treated mice is only 19% of that of normal mice down