Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glucose-6-phosphate | 10 mM, recombinant enzyme is 3fold activated | Brugia malayi |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Brugia malayi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | 20 mM, 96% inhibition | Brugia malayi | |
ADP | 0.0001 mM, 50% inhibition. Noncompetitive inhibition with the substrate glucose | Brugia malayi | |
CaCl2 | 10 mM, 98% inhibition | Brugia malayi | |
D-glucosamine | - |
Brugia malayi | |
D-glucose 6-phosphate | - |
Brugia malayi | |
diphosphate | mixed type of inhibition when ATP is used as substrate | Brugia malayi | |
EDTA | 40 mM, 91% inhibition | Brugia malayi | |
KCl | 10 mM, 92% inhibition | Brugia malayi | |
mannoheptulose | - |
Brugia malayi | |
Mg2+ | 100 mM, 72% inhibition | Brugia malayi | |
N-acetyl glucosamine | - |
Brugia malayi | |
NaCl | 10 mM, 96% inhibition | Brugia malayi | |
p-chloromercuribenzoate | 0.05 mM, 72% inhibition | Brugia malayi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.035 | - |
D-glucose | - |
Brugia malayi | |
1.09 | - |
ATP | - |
Brugia malayi | |
75 | - |
D-fructose | - |
Brugia malayi |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
4 * 72000, SDS-PAGE | Brugia malayi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brugia malayi | Q56VN6 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Brugia malayi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-fructose | - |
Brugia malayi | ADP + D-fructose 6-phosphate | - |
? | |
ATP + D-galactose | - |
Brugia malayi | ? | - |
? | |
ATP + D-glucose | - |
Brugia malayi | ADP + D-glucose 6-phosphate | - |
? | |
ATP + D-maltose | - |
Brugia malayi | ? | - |
? | |
ATP + D-mannose | - |
Brugia malayi | ADP + D-mannose 6-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 72000, SDS-PAGE | Brugia malayi |
Synonyms | Comment | Organism |
---|---|---|
BmHk | - |
Brugia malayi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
- |
Brugia malayi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
diphosphate | - |
Brugia malayi | |
0.55 | - |
ADP | substrate glucose | Brugia malayi |