Literature summary for 2.7.1.1 extracted from

Sanz, C.; Roncero, I.; Vazquez, P.; Navas, M.A.; Blazquez, E.
Effects of glucose and insulin on glucokinase activity in rat hypothalamus (2007), J. Endocrinol., 193, 259-267.

Search for more literature for 2.7.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in GT1-7 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Insulin	decreases glucokinase activity at 5.5 mM glucose and at 10 mM glucose. No effect at 2.8 mM glucose or at 20 mM glucose	Rattus norvegicus
leptin	decreases glucokinase activity at all glucose concentrations tested	Rattus norvegicus
neuropeptide Y	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hypothalamus	enzyme activities increase in the ventromedial hypothalamus as the glucose concentration rises. Enzyme activities in lateral hypothalamus decreases at 2.8 mM and 20 mM glucose	Rattus norvegicus	-

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Release 2023.1 (January 2023)