Literature summary for 2.7.1.1 extracted from

Futamura, M.; Hosaka, H.; Kadotani, A.; Shimazaki, H.; Sasaki, K.; Ohyama, S.; Nishimura, T.; Eiki, J.; Nagata, Y.
An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism (2006), J. Biol. Chem., 281, 37668-37674.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the allosteric activator compound A, increases the level of cytoplasmic glucokinase in both isolated rat primary hepatocytes and the liver tissues from rats. Compound A interacts with glucose-bound free GK, thereby impairing the association of glucokinase and glucokinase regulatory protein	Rattus norvegicus

Application

Application	Comment	Organism
medicine	given the combined prominent role of glucokinase on insulin secretion and hepatic glucose metabolism where the GK-GKRP mechanism is involved, activation of glucokinase has a new therapeutic potential in the treatment of type 2 diabetes	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

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Release 2023.1 (January 2023)