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Literature summary for 2.7.1.1 extracted from

  • Marin-Hernandez, A.; Rodriguez-Enriquez, S.; Vital-Gonzalez, P.A.; Flores-Rodriguez, F.L.; Macias-Silva, M.; Sosa-Garrocho, M.; Moreno-Sanchez, R.
    Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase (2006), FEBS J., 273, 1975-1988.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
D-glucose 6-phosphate hexokinase activity is strongly inhibited by high, but physiological, concentrations of glucose 6-phosphate Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
AS-30D cell 153-306 times higher overexpression in rat AS-30D hepatoma cells than in normal freshly isolated rat hepatocytes. The enhanced glycolytic flux in fast-growth tumor cells is controlled by an overproduced, but glucose 6-phosphate-inhibited hexokinase Rattus norvegicus
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HeLa cell overproduction of hexokinase Homo sapiens
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hepatocyte 153-306 times higher overexpression in rat AS-30D hepatoma cells than in normal freshly isolated rat hepatocytes Rattus norvegicus
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