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Literature summary for 2.7.1.1 extracted from

  • Heredia, V.V.; Thomson, J.; Nettleton, D.; Sun, S.
    Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis (2006), Biochemistry, 45, 7553-7562.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y214C the glucose binding affinity is increased while its cooperativity is decreased Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
ATP cosubstrate: glucose, wild-type enzyme Homo sapiens
0.23
-
D-glucose mutant enzyme Y214C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinantly expressed in Escherichia coli
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-deoxy-D-glucose
-
Homo sapiens ADP + 2-deoxy-D-glucose 6-phosphate
-
?
ATP + D-glucose
-
Homo sapiens ADP + D-glucose 6-phosphate
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
29
-
2-deoxy-D-glucose wild-type enzyme Homo sapiens
38
-
D-glucose wild-type enzyme Homo sapiens
39
-
D-glucose mutant enzyme Y214C Homo sapiens