Literature summary for 2.7.1.1 extracted from

Aubert-Foucher, E.; Font, B.; Gautheron, D.C.
Rabbit heart mitochondrial hexokinase: solubilization and general properties (1984), Arch. Biochem. Biophys., 232, 391-399.

Search for more literature for 2.7.1.1

Inhibitors

Inhibitors	Comment	Organism	Structure
ATP	ATP4-; potent inhibitor of mitochondrial HK I	Oryctolagus cuniculus
D-glucose 6-phosphate	potent inhibitor of mitochondrial HK I	Oryctolagus cuniculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.062	0.065	D-glucose	bound and solubilized mitochondrial HK I, at pH 7.5	Oryctolagus cuniculus
0.075	-	ATP	MgATP2-, bound mitochondrial HK I, at pH 7.5	Oryctolagus cuniculus
0.181	-	ATP	MgATP2-, solubilized mitochondrial HK I, at pH 7.5	Oryctolagus cuniculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrial outer membrane	HK I, 2 kinds of interactions between HK I and mitochondria: a very specific one with the hexokinase-binding protein of the outer mitochondrial membrane, which is supressed by glucose 6-phosphate, and a less specific, cation-mediated one	Oryctolagus cuniculus	5741	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glucose + ATP	Oryctolagus cuniculus	glucose metabolism	D-glucose 6-phosphate + ADP	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	2 isoenzymes: mitochondrial HK I and a soluble HK	-

Purification (Commentary)

Purification (Comment)	Organism
solubilization studies of mitochondrial HK I	Oryctolagus cuniculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	2 isoenzymes	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose + ATP	-	Oryctolagus cuniculus	ADP + D-glucose 6-phosphate	-	?
D-glucose + ATP	glucose metabolism	Oryctolagus cuniculus	D-glucose 6-phosphate + ADP	-	?

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)