Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-glucose 6-phosphate | inhibitor blocks the action of hexokinase by effecting a conformational change in the structure of enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | enzyme has the ability to associate with cellular organelles, this association indicates a conformational equilibrium which is strikingly influenced by glucose 6-phosphate | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
110000 | - |
1 * 110000, heart hexokinase, monomer with a tendency to form aggregates, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + ATP | Homo sapiens | initial enzyme of glycolysis | D-glucose 6-phosphate + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
from blood: 175000fold, from heart: 1700fold | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
37 | - |
hexokinase from blood, at 25°C | Homo sapiens |
58 | - |
hexokinase from heart, at 25°C, pH 7.2 | Homo sapiens |
150 | - |
hexokinase from heart, at 25°C, pH 8 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + ATP | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? | |
D-glucose + ATP | initial enzyme of glycolysis | Homo sapiens | D-glucose 6-phosphate + ADP | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 110000, heart hexokinase, monomer with a tendency to form aggregates, SDS-PAGE | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |