Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acidic phospholipids | irreversible inhibition, binds at the nucleotide-binding site of enzyme, ATP and glucose 6-phosphate protect, effectiveness of various ligands in protection against inhibition, effect of pH and temperature | Rattus norvegicus | |
cardiolipin | effectiveness of various ligands in protection against inhibition, effect of pH and temperature | Rattus norvegicus | |
Cibacron blue | competitive to ATP | Rattus norvegicus | |
D-glucose 6-phosphate | reversible product inhibition | Rattus norvegicus | |
additional information | not inhibited by 1 mM phosphatidylethanolamine or phosphatidylcholine | Rattus norvegicus | |
phosphatidylinositol | effectiveness of various ligands in protection against inhibition, effect of pH and temperature | Rattus norvegicus | |
phosphatidylserine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo | Rattus norvegicus | 5741 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + ATP | Rattus norvegicus | binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate | D-glucose 6-phosphate + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + ATP | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? | |
D-glucose + ATP | binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate | Rattus norvegicus | D-glucose 6-phosphate + ADP | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |