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Literature summary for 2.6.99.2 extracted from

  • Cane, D.E.; Du, S.; Robinson, J.K.; Hsiung, Y.; Spenser, I.D.
    Biosynthesis of vitamin B6: enzymatic conversion of 1-deoxy-D-xylulose-5-phosphate to pyridoxol phosphate (1999), J. Am. Chem. Soc., 121, 7722-7723.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Escherichia coli the enzyme is involved in biosynthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Reaction

Reaction Comment Organism Reaction ID
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O reaction mechanism, the enzyme shows phosphomutase activity Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate the enzyme is involved in biosynthesis of vitamin B6 Escherichia coli pyridoxine 5'-phosphate + phosphate + H2O
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?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate the enzyme shows phosphomutase activity transfering the 5-phosphoryl group of 1-deoxy-D-xylose 5-phosphate to the 4-hydroxyl at some point in the reaction, the phosphate group of the substrate is required for activity, reaction mechanism, overview Escherichia coli pyridoxine 5'-phosphate + phosphate + H2O i.e. pyridoxol phosphate ?
additional information free alcohol deoxyxylulose is no substrate Escherichia coli ?
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Synonyms

Synonyms Comment Organism
PdxJ
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Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Escherichia coli