Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate | Amycolatopsis orientalis | - |
4-hydroxybenzoylformate + L-tyrosine | - |
r | |
4-hydroxybenzoylformate + L-tyrosine | Amycolatopsis orientalis | biosynthetic direction | (2S)-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate | - |
r | |
additional information | Amycolatopsis orientalis | no amino acceptors: D-4-hydroxyphenylglycine, glutamate, pyruvate, oxaloacetate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Amycolatopsis orientalis | O52815 | cf. EC 2.6.1.103 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
4-hydroxybenzoylformate + L-tyrosine = (2S)-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate | biosynthetic direction | Amycolatopsis orientalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate | - |
Amycolatopsis orientalis | 4-hydroxybenzoylformate + L-tyrosine | - |
r | |
4-hydroxybenzoylformate + 3-chloro-L-tyrosine | - |
Amycolatopsis orientalis | L-4-hydroxyphenylglycine + 3-chloro-4-hydroxyphenylpyruvate | - |
? | |
4-hydroxybenzoylformate + L-phenylalanine | - |
Amycolatopsis orientalis | (2S)-4-hydroxyphenylglycine + phenylpyruvate | - |
? | |
4-hydroxybenzoylformate + L-tyrosine | biosynthetic direction | Amycolatopsis orientalis | (2S)-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate | - |
r | |
benzoylformate + L-tyrosine | - |
Amycolatopsis orientalis | L-phenylalanine + 4-hydroxyphenylpyruvate | - |
? | |
additional information | no amino acceptors: D-4-hydroxyphenylglycine, glutamate, pyruvate, oxaloacetate | Amycolatopsis orientalis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 47777, calculated | Amycolatopsis orientalis |
Synonyms | Comment | Organism |
---|---|---|
4-hydroxyphenylglycine transaminase | - |
Amycolatopsis orientalis |
HpgT | - |
Amycolatopsis orientalis |
p-hydroxyphenylglycine transaminase | - |
Amycolatopsis orientalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | exogenous pyridoxal 5'-phosphate is required for catalytic activity | Amycolatopsis orientalis |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme is part of the chloroeremomycin biosynthetic cluster. Non-heme iron dioxygenase HmaS catalyzes the synthesis of L-4-hydroxymandelate from 4-hydroxyphenylpyruvate. The L-4-hydroxymandelate is subsequently converted to L-4-hydroxyphenylglycine via L-4-hydroxymandelate oxidase Hmo catalyzed conversion of L-4-hydroxymandelate to L-4-hydroxybenzoylformate followed by 4-hydroxyphenylglycine transaminase HpgT catalyzed transamination of 4-hydroxybenzoylformate to 4-hydroxyphenylglycine. The biosynthesis of L-4-hydroxyphenylglycine is proposed to be a catalytic cycle initiated by the production of 4-hydroxyphenylpyruvate | Amycolatopsis orientalis |