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Literature summary for 2.6.1.99 extracted from

  • Stepanova, A.; Yun, J.; Robles, L.; Novak, O.; He, W.; Guo, H.; Ljung, K.; Alonso, J.
    The Arabidopsis YUCCA1 flavin monooxygenase functions in the indole-3-pyruvic acid branch of auxin biosynthesis (2011), Plant Cell, 23, 3961-3973.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.99

Protein Variants

Protein Variants Comment Organism
additional information construction of wei8 knockout mutants and of wei8-1 and tar2-1 mutants. If TAA1/TARs and YUCs work together to produce indole 3-acetic acid, blocking the in vivo activity of TAA1/TARs with L-kynurenine suppresses the high-auxin phenotypes of YUC1ox plants. The plants expressing the YUC1 cDNA under the control of the TAA1 regulatory sequences display a much stronger root phenotype, characterized by an extremely short root length both in light- and dark-grown seedlings. Significantly lower levels of free for indole 3-acetic acid are detected in the single wei8-2 as well as in the double wei8-2 tar2-1 mutants Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
L-kynurenine a potent inhibitor of in vivo TAA1/TAR activity Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + pyruvate Arabidopsis thaliana
-
 indole-3-pyruvate + L-alanine
-
 ?
L-tryptophan + pyruvate Arabidopsis thaliana Col-0
-
 indole-3-pyruvate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9S7N2 gene wei8
-
Arabidopsis thaliana Col-0 Q9S7N2 gene wei8
-

Source Tissue

Source Tissue Comment Organism Textmining
root
-
 Arabidopsis thaliana
-
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + pyruvate
-
 Arabidopsis thaliana indole-3-pyruvate + L-alanine
-
 ?
L-tryptophan + pyruvate
-
 Arabidopsis thaliana Col-0 indole-3-pyruvate + L-alanine
-
 ?

Synonyms

Synonyms Comment Organism
tryptophan aminotransferase of Arabidopsis 1
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction significantly lower levels of free for indole 3-acetic acid are detected in the single wei8-2 as well as in the double wei8-2 tar2-1 mutants Arabidopsis thaliana
metabolism the three gene families, cytochrome P450 79B2/B3, YUCCA or YUC, and tryptophan aminotransferase of Arabidopsis 1/tryptopan aminotransferase related, i.e. TAA1/TAR, in the production of this hormone in the reference plant Arabidopsis thaliana. Each of these three gene families is believed to represent independent routes of auxin biosynthesis. TAA1/TARs and YUCs function in a common linear biosynthetic pathway that is genetically distinct from the CYP79B2/B3 route. In the redefined TAA1-YUC auxin biosynthetic pathway, TAA1/TARs are required for the production of indole-3-pyruvic acid from Trp, whereas YUCs are likely to function downstream, function of TAA1 and TARs is required for indole 3-acetic acid production via YUCs. Enzymatic reactions involved in indole-3-acetic acid production via indole-3-pyruvic acid, overview. The CYP79B2/B3 function is not required for YUC1-mediated auxin production Arabidopsis thaliana
additional information if TAA1/TARs and YUCs work together to produce indole 3-acetic acid, blocking the in vivo activity of TAA1/TARs with L-kynurenine suppresses the high-auxin phenotypes of YUC1ox plants Arabidopsis thaliana