Literature summary for 2.6.1.81 extracted from

Vander Wauven, C.; Stalon, V.
Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia (1985), J. Bacteriol., 164, 882-886.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	arginine induces the enzyme, enzyme induction by arginine is diminished by addition of succinate, L-glutamate or NH4+ in the growth medium, overview	Burkholderia cepacia

Inhibitors

Inhibitors	Comment	Organism	Structure
aminooxoacetic acid	-	Burkholderia cepacia
additional information	arginine induces the enzyme, enzyme induction by arginine is diminished by addition of succinate, L-glutamate or NH4+ in the growth medium, overview	Burkholderia cepacia

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.25	-	N2-succinyl-L-ornithine	pH 8.5, 37°C, cell extract	Burkholderia cepacia

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate	Burkholderia cepacia	step in metabolic conversion of L-arginine into L-glutamate, pathway overview	N-succinyl-L-glutamate 5-semialdehyde + L-glutamate	-	?

Organism

Organism	UniProt	Comment	Textmining
Burkholderia cepacia	-	-	-
Burkholderia cepacia NCTC 10743	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
culture condition:arginine-grown cell	-	Burkholderia cepacia	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.027	-	succinate/ammonium-grown cells, cell extract	Burkholderia cepacia
1.07	-	arginine-grown cells, induced enzyme, cell extract	Burkholderia cepacia

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate	-	Burkholderia cepacia	N-succinyl-L-glutamate 5-semialdehyde + L-glutamate	-	?
N2-succinyl-L-ornithine + 2-oxoglutarate	step in metabolic conversion of L-arginine into L-glutamate, pathway overview	Burkholderia cepacia	N-succinyl-L-glutamate 5-semialdehyde + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
succinylornithine aminotransferase	-	Burkholderia cepacia

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Burkholderia cepacia

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.6	-	-	Burkholderia cepacia

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Burkholderia cepacia

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Release 2023.1 (January 2023)