Application | Comment | Organism |
---|---|---|
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter calcoaceticus |
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter johnsonii |
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter lwoffii |
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter baumannii |
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter genospecies |
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter haemolyticus |
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter junii |
medicine | drug development, Acinetobacter sp. can be part of the normal flora of human skin but also of opportunistic infections like septicemia, pneumonia, endocarditis, meningitis, skin and wound sepsis or urinary tract infections, clinically important isolates show widespread and increasing resistance to many commonly used antibiotics | Acinetobacter radioresistens |
Cloned (Comment) | Organism |
---|---|
homologs of dat detected by PCR amplification | Acinetobacter calcoaceticus |
homologs of dat detected by PCR amplification | Acinetobacter johnsonii |
homologs of dat detected by PCR amplification | Acinetobacter lwoffii |
homologs of dat detected by PCR amplification | Acinetobacter genospecies |
homologs of dat detected by PCR amplification | Acinetobacter haemolyticus |
homologs of dat detected by PCR amplification | Acinetobacter junii |
homologs of dat detected by PCR amplification | Acinetobacter radioresistens |
identification and analysis of the dat gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase with Escherichia coli transformants | Acinetobacter baumannii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.46 | - |
2-oxoglutaric acid | - |
Acinetobacter baumannii | |
4.3 | - |
L-2,4-diaminobutyric acid | - |
Acinetobacter baumannii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
4 * 45000, SDS-PAGE | Acinetobacter baumannii |
47420 | - |
deduced from nucleotide sequence | Acinetobacter baumannii |
188000 | - |
native enzyme, gel filtration | Acinetobacter baumannii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acinetobacter baumannii | - |
- |
- |
Acinetobacter calcoaceticus | - |
- |
- |
Acinetobacter genospecies | - |
3 ATCC 19004 | - |
Acinetobacter haemolyticus | - |
ATCC 17906 | - |
Acinetobacter johnsonii | - |
ATCC 17909 | - |
Acinetobacter junii | - |
ATCC 17908 | - |
Acinetobacter lwoffii | - |
ATCC 15309 | - |
Acinetobacter radioresistens | - |
IAM13186 | - |
Acinetobacter radioresistens IAM13186 | - |
IAM13186 | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme, overexpressed in Escherichia coli | Acinetobacter baumannii |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate | Involved in the formation of 1,3-diaminopropane in Haemophilus influenzae and Acinetobacter baumannii. A product of the ddc gene that also encodes L-2,4-diaminobutyrate decarboxylase in Acinetobacter baumannii. Differs from EC 2.6.1.46 diaminobutyrate-pyruvate transaminase, which has pyruvate as the amino-group acceptor | Acinetobacter baumannii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-alanine + 2-oxoglutaric acid | - |
Acinetobacter baumannii | ? | - |
? | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter calcoaceticus | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter johnsonii | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter lwoffii | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter baumannii | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter genospecies | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter haemolyticus | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter junii | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter radioresistens | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
Acinetobacter radioresistens IAM13186 | L-glutamic acid + L-aspartic beta-semialdehyde | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter calcoaceticus | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter johnsonii | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter lwoffii | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter baumannii | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter genospecies | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter haemolyticus | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter junii | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter radioresistens | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-glutamic acid + L-aspartic beta-semialdehyde | - |
Acinetobacter radioresistens IAM13186 | L-2,4-diaminobutyric acid + 2-oxoglutaric acid | - |
r | |
L-lysine + oxaloacetic acid | - |
Acinetobacter baumannii | ? | - |
? | |
L-ornithine + pyruvic acid | - |
Acinetobacter baumannii | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 45000, SDS-PAGE | Acinetobacter baumannii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.25 | 8.75 | - |
Acinetobacter baumannii |