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Literature summary for 2.6.1.7 extracted from

  • Yoshida, Y.; Fujigaki, H.; Kato, K.; Yamazaki, K.; Fujigaki, S.; Kunisawa, K.; Yamamoto, Y.; Mouri, A.; Oda, A.; Nabeshima, T.; Saito, K.
    Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues (2019), Sci. Rep., 9, 10243 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine isoform KAT2 is a therapeutic target for the management of schizophrenia Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BFF-122
-
Homo sapiens
BFF-816
-
Homo sapiens
carbenoxolone highly selective and competitive inhibitor for isoform KAT2 Homo sapiens
glycyrrhetinic acid highly selective and competitive inhibitor for isoform KAT2 Homo sapiens
glycyrrhizic acid highly selective and competitive inhibitor for isoform KAT2 Homo sapiens
PF-04859989
-
Homo sapiens
S-4-(ethylsulfonyl)benzoyl-L-alanine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-kynurenine + 2-oxoglutarate Homo sapiens
-
kynurenic acid + L-glutamate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N5Z0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate
-
Homo sapiens kynurenic acid + L-glutamate + H2O
-
?

Synonyms

Synonyms Comment Organism
KAT2
-
Homo sapiens
kynurenine aminotransferase 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0039
-
isoform KAT2, at pH 9.5 and 37°C Homo sapiens carbenoxolone
0.00451
-
isoform KAT2, at pH 9.5 and 37°C Homo sapiens glycyrrhizic acid
0.00696
-
isoform KAT2, at pH 9.5 and 37°C Homo sapiens glycyrrhetinic acid