Application | Comment | Organism |
---|---|---|
medicine | isoform KAT2 is a therapeutic target for the management of schizophrenia | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BFF-122 | - |
Homo sapiens | |
BFF-816 | - |
Homo sapiens | |
carbenoxolone | highly selective and competitive inhibitor for isoform KAT2 | Homo sapiens | |
glycyrrhetinic acid | highly selective and competitive inhibitor for isoform KAT2 | Homo sapiens | |
glycyrrhizic acid | highly selective and competitive inhibitor for isoform KAT2 | Homo sapiens | |
PF-04859989 | - |
Homo sapiens | |
S-4-(ethylsulfonyl)benzoyl-L-alanine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | Homo sapiens | - |
kynurenic acid + L-glutamate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N5Z0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | - |
Homo sapiens | kynurenic acid + L-glutamate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KAT2 | - |
Homo sapiens |
kynurenine aminotransferase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0039 | - |
isoform KAT2, at pH 9.5 and 37°C | Homo sapiens | carbenoxolone | |
0.00451 | - |
isoform KAT2, at pH 9.5 and 37°C | Homo sapiens | glycyrrhizic acid | |
0.00696 | - |
isoform KAT2, at pH 9.5 and 37°C | Homo sapiens | glycyrrhetinic acid |