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Literature summary for 2.6.1.7 extracted from

  • Baran, H.; Amann, G.; Lubec, B.; Lubec, G.
    Kynurenic acid and kynurenine aminotransferase in heart (1997), Pediatr. Res., 41, 404-410.
    View publication on PubMed
Search for more literature for 2.6.1.7

Activating Compound

Activating Compound Comment Organism Structure
L-tryptophan 2 mM, 84% increase in activity of heart KAT at pH 8.0 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-tryptophan
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.62
-
 2-oxoglutarate pH 8.0, 37°C, heart KAT, at 5 mM L-kynurenine Homo sapiens
1.15
-
 pyruvate pH 8.0, 37°C, heart KAT, at 5 mM L-kynurenine Homo sapiens
20
-
 L-kynurenine pH 8.0, 37°C, heart KAT, cosubstrate 5 mM pyruvate Homo sapiens
27
-
 L-kynurenine pH 8.0, 37°C, heart KAT, cosubstrate 5 mM 2-oxoglutarate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoadipate
-
 Homo sapiens kynurenic acid + 2-aminoadipate + H2O
-
 ?
L-kynurenine + 2-oxoisohexanoate heart KAT, low activity Homo sapiens kynurenic acid + 2-aminoisohexanoate + H2O
-
 ?
L-kynurenine + pyruvate best substrate of heart KAT Homo sapiens kynurenic acid + L-alanine + H2O
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 9 heart enzyme Homo sapiens