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Literature summary for 2.6.1.7 extracted from

  • Malherbe, P.; Alberati-Giani, D.; Koehler, C.; Cesura, A.M.
    Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain (1995), FEBS Lett., 367, 141-144.
    View publication on PubMed
Search for more literature for 2.6.1.7

Cloned(Commentary)

Cloned (Comment) Organism
transient expression in HEK-293 cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.096
-
 2-oxoglutarate pH 8.0, 37°C, recombinant mitochondrial enzyme Rattus norvegicus
1.63
-
 pyruvate pH 8.0, 37°C, recombinant mitochondrial enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion cDNA encodes for a kynurenine aminotransferase that is identical to a soluble form but carries an additional stretch of 32 amino acids resembling a mitochondrial import sequence Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q08415 brain KAT I
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate enzyme has both kynurenine aminotransferase and glutamine transaminase K activity Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
L-kynurenine + pyruvate
-
 Rattus norvegicus kynurenic acid + L-alanine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
KAT
-
 Rattus norvegicus