Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-kynurenine | substrate inhibition above 6 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.5 | - |
L-3-hydroxykynurenine | pH 7.2, 37°C, kidney mitochondria | Rattus norvegicus | |
2.5 | - |
L-kynurenine | pH 7.2, 37°C, kidney supernatant | Rattus norvegicus | |
3 | - |
L-kynurenine | pH 7.2, 37°C, liver supernatant | Rattus norvegicus | |
3.4 | - |
L-kynurenine | pH 7.2, 37°C, kidney mitochondria | Rattus norvegicus | |
5 | - |
L-kynurenine | pH 7.2, 37°C, liver mitochondria | Rattus norvegicus | |
5 | - |
L-3-hydroxykynurenine | pH 7.2, 37°C, liver supernatant | Rattus norvegicus | |
5.3 | - |
L-3-hydroxykynurenine | pH 7.2, 37°C, kidney supernatant | Rattus norvegicus | |
6.3 | - |
L-3-hydroxykynurenine | pH 7.2, 37°C, liver mitochondria | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | 80% of liver total activity | Rattus norvegicus | 5739 | - |
mitochondrion | 40% of kidney total activity | Rattus norvegicus | 5739 | - |
additional information | subcellular distribution | Rattus norvegicus | - |
- |
soluble | 60% of kidney total activity | Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3-hydroxykynurenine + 2-oxoglutarate | - |
Rattus norvegicus | xanthurenic acid + L-glutamate | - |
? | |
L-kynurenine + 2-oxoglutarate | - |
Rattus norvegicus | kynurenic acid + L-glutamate + H2O | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |