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Literature summary for extracted from

  • Dai, R.; Wilson, D.J.; Geders, T.W.; Aldrich, C.C.; Finzel, B.C.
    Inhibition of Mycobacterium tuberculosis transaminase BioA by aryl hydrazines and hydrazides (2014), ChemBioChem, 15, 575-586.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with substrate 7-oxo-8-aminopelargonic acid and in complex with inhibitors 1-(1,3-benzothiazol-2-yl)methanamine and 2-hydrazinyl-1,3-benzothiazole. The side chains of Tyr25, Trp65, Arg400, and Tyr407 are shown to be quite flexible. Small molecule binding induces unexpected conformational remodeling in the substrate binding site Mycobacterium tuberculosis


Inhibitors Comment Organism Structure
Mycobacterium tuberculosis
2-hydrazinyl-1,3-benzothiazole reversible covalent inhibitor Mycobacterium tuberculosis


Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQ81
Mycobacterium tuberculosis H37Rv P9WQ81


Synonyms Comment Organism
Mycobacterium tuberculosis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
melting temperature, in complex with inhibitor 2-hydrazinyl-1,3-benzothiazole Mycobacterium tuberculosis
melting temperature, in complex with inhibitor 1-(1,3-benzothiazol-2-yl)methanamine Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2-hydrazinyl-1,3-benzothiazole pH 8.6, 25°C Mycobacterium tuberculosis