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Literature summary for 2.6.1.62 extracted from

  • Dai, R.; Wilson, D.J.; Geders, T.W.; Aldrich, C.C.; Finzel, B.C.
    Inhibition of Mycobacterium tuberculosis transaminase BioA by aryl hydrazines and hydrazides (2014), ChemBioChem, 15, 575-586.
    View publication on PubMed
Search for more literature for 2.6.1.62

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with substrate 7-oxo-8-aminopelargonic acid and in complex with inhibitors 1-(1,3-benzothiazol-2-yl)methanamine and 2-hydrazinyl-1,3-benzothiazole. The side chains of Tyr25, Trp65, Arg400, and Tyr407 are shown to be quite flexible. Small molecule binding induces unexpected conformational remodeling in the substrate binding site Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
1-(1,3-benzothiazol-2-yl)methanamine
-
 Mycobacterium tuberculosis
2-hydrazinyl-1,3-benzothiazole reversible covalent inhibitor Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQ81
-
-
Mycobacterium tuberculosis H37Rv P9WQ81
-
-

Synonyms

Synonyms Comment Organism
bioA
-
 Mycobacterium tuberculosis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
67
-
 melting temperature, in complex with inhibitor 2-hydrazinyl-1,3-benzothiazole Mycobacterium tuberculosis
78
-
 melting temperature, in complex with inhibitor 1-(1,3-benzothiazol-2-yl)methanamine Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
 2-hydrazinyl-1,3-benzothiazole pH 8.6, 25°C Mycobacterium tuberculosis