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Literature summary for 2.6.1.59 extracted from

  • Ohashi, H.; Matsuhashi, M.; Matsuhashi, S.
    Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. IV. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Pasteurella pseudotuberculosis (1971), J. Biol. Chem., 246, 2325-2330.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Maleate stabilizing effect Yersinia pseudotuberculosis

General Stability

General Stability Organism
crude extract and partially purified enzyme are unstable, necessity of addition of pyridoxal phosphate during purification Yersinia pseudotuberculosis
maleate enhances stabilizing effect of pyridoxal phosphate Yersinia pseudotuberculosis

Inhibitors

Inhibitors Comment Organism Structure
L-cysteine strong Yersinia pseudotuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
TDP-4-amino-4,6-dideoxy-D-galactose pH 7.0, 38°C Yersinia pseudotuberculosis
0.22
-
2-oxoglutarate pH 7.0, 38°C Yersinia pseudotuberculosis
1
-
TDP-4-keto-6-deoxy-D-glucose pH 7.0, 38°C Yersinia pseudotuberculosis
7.9
-
L-glutamate pH 7.0, 38°C Yersinia pseudotuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate Yersinia pseudotuberculosis
-
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
-
?
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate Yersinia pseudotuberculosis VO
-
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Yersinia pseudotuberculosis
-
type VO
-
Yersinia pseudotuberculosis VO
-
type VO
-

Purification (Commentary)

Purification (Comment) Organism
partial Yersinia pseudotuberculosis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.01
-
pH 7.0, 38°C Yersinia pseudotuberculosis

Storage Stability

Storage Stability Organism
0°C or -15°C, purified enzyme, stable for several weeks Yersinia pseudotuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
-
Yersinia pseudotuberculosis dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
-
?
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
-
Yersinia pseudotuberculosis VO dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
-
?
additional information little activity with L-glutamine or L-alanine Yersinia pseudotuberculosis ?
-
?
additional information little activity with L-glutamine or L-alanine Yersinia pseudotuberculosis VO ?
-
?
TDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
-
Yersinia pseudotuberculosis TDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
-
r
TDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
-
Yersinia pseudotuberculosis VO TDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
38
-
assay at Yersinia pseudotuberculosis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
10 min: 7% remaining activity, 72% remaining activity with addition of pyridoxal 5'-phosphate, 86% remaining activity with addition of pyridoxal 5'-phosphate and potassium maleate Yersinia pseudotuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Yersinia pseudotuberculosis

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate absolute requirement, a pyridoxal phosphate protein Yersinia pseudotuberculosis