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Literature summary for 2.6.1.57 extracted from

  • Bode, R.; Birnbaum, D.
    Charakterisierung von drei aromatischen Aminotransferasen aus Candida maltosa (1984), Z. Allg. Mikrobiol., 24, 67-75.
No PubMed abstract available
Search for more literature for 2.6.1.57

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxyphenylpyruvate substrate inhibition Candida maltosa
Indole pyruvate substrate inhibition Candida maltosa
phenylpyruvate substrate inhibition Candida maltosa
prephenate substrate inhibition Candida maltosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km values of AAT I and II are very similar for a variety of substrates, Km values for AAT II are higher Candida maltosa
0.001
-
 pyridoxal 5'-phosphate pH 8.6, 37°C, AAT I Candida maltosa
0.05
-
 4-hydroxyphenylpyruvate pH 8.6, 37°C, AAT I Candida maltosa
0.06
-
 Indolepyruvate pH 8.6, 37°C, AAT I Candida maltosa
0.08
-
 phenylpyruvate pH 8.6, 37°C, AAT I Candida maltosa
0.08
-
 prephenate pH 8.6, 37°C, AAT I Candida maltosa
0.4
-
 L-tyrosine pH 8.6, 37°C, AAT I Candida maltosa
0.44
-
 L-phenylalanine pH 8.6, 37°C, AAT I Candida maltosa
0.45
-
 L-arogenate pH 8.6, 37°C, AAT I Candida maltosa
2.5
-
 L-tryptophan pH 8.6, 37°C, AAT I Candida maltosa
3.3
-
 oxaloacetate pH 8.6, 37°C, AAT I Candida maltosa
4
-
 L-leucine pH 8.6, 37°C, AAT I Candida maltosa
5
-
 2-oxoglutarate pH 8.6, 37°C, AAT I Candida maltosa
5
-
 L-methionine pH 8.6, 37°C, AAT I Candida maltosa
5
-
 L-histidine pH 8.6, 37°C, AAT I Candida maltosa
7
-
 L-glutamine pH 8.6, 37°C, AAT I Candida maltosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
73000
-
 isoenzyme AAT-I, gel filtration Candida maltosa
85000
-
 isoenzyme AAT-II, gel filtration Candida maltosa
105000
-
 isoenzyme AAT-III, gel filtration Candida maltosa

Organism

Organism UniProt Comment Textmining
Candida maltosa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-cellulose, isolation of isoenzymes AAT I, AAT II and AAT III Candida maltosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arogenate + indolepyruvate
-
 Candida maltosa L-tryptophan + 3-(1-carboxy-4-hydroxycyclohexa-2,5-dienyl)2-oxopropanoate
-
 ?
L-glutamine + indole pyruvate AAT I and II Candida maltosa 2-oxoglutamine + L-tryptophan
-
 ?
L-histidine + indole pyruvate
-
 Candida maltosa 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-tryptophan
-
 ?
L-leucine + indole pyruvate
-
 Candida maltosa 4-methyl-2-oxopentanoate + L-tryptophan
-
 ?
L-methionine + indole pyruvate AAT I and II Candida maltosa 4-methylsulfanyl-2-oxobutanoate + L-tryptophan
-
 ?
L-phenylalanine + 2-oxoglutarate completely inactive with D-isomers of aromatic amino acids Candida maltosa phenylpyruvate + L-glutamate
-
 ?
L-phenylalanine + 2-oxoglutarate specificities of isoenzymes: AAT I, AAT II, AAT III Candida maltosa phenylpyruvate + L-glutamate
-
 ?
L-tryptophan + 2-oxoglutarate
-
 Candida maltosa 3-indole-2-oxopropanoate + L-glutamate
-
 ?
L-tryptophan + indole pyruvate
-
 Candida maltosa 3-indole-2-oxopropanoate + L-tryptophan
-
 ?
L-tryptophan + oxaloacetate
-
 Candida maltosa 3-indole-2-oxopropanoate + L-aspartate
-
 ?
L-tryptophan + phenylpyruvate
-
 Candida maltosa 3-indole-2-oxopropanoate + L-phenylalanine
-
 ?
L-tyrosine + 2-oxoglutarate
-
 Candida maltosa p-hydroxyphenylpyruvate + L-glutamate
-
 ?
L-tyrosine + indole pyruvate
-
 Candida maltosa 4-hydroxyphenylpyruvate + L-tryptophan
-
 ?
prephenate + L-glutamate
-
 Candida maltosa 1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate
-
 ?
prephenate + L-tryptophan
-
 Candida maltosa 1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 3-indole-2-oxopropanoate
-
 ?

Synonyms

Synonyms Comment Organism
AAT I-III i.e. aromatic aminotransferase I, II and III Candida maltosa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate a pyridoxal phosphate protein Candida maltosa
pyridoxal 5'-phosphate Km: 0.001 mM, isoenzyme AAT I, 0.0005 mM, isoenzyme AAT II, AAT III Candida maltosa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.3
-
 indolpyruvate AAT I, substrate inhibition Candida maltosa
0.3
-
 4-hydroxyphenylpyruvate AAT III, substrate inhibition Candida maltosa
0.3
-
 indolpyruvate AAT I and III, substrate inhibition Candida maltosa
0.4
-
 prephenate AAT I, substrate inhibition Candida maltosa
0.4
-
 4-hydroxyphenylpyruvate AAT I, substrate inhibition Candida maltosa
0.4
-
 prephenate AAT I and III, substrate inhibition Candida maltosa
0.5
-
 phenylpyruvate AAT I, substrate inhibition Candida maltosa
0.5
-
 phenylpyruvate AAT III, substrate inhibition Candida maltosa
1.5
-
 indolpyruvate AAT II, substrate inhibition Candida maltosa
10
-
 4-hydroxyphenylpyruvate AAT II, substrate inhibition Candida maltosa
15
-
 phenylpyruvate AAT II, substrate inhibition Candida maltosa
15
-
 prephenate AAT II, substrate inhibition Candida maltosa