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Literature summary for 2.6.1.51 extracted from
- Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase (1999), J. Biol. Chem., 274, 16028-16033.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | absence of human SPT/AGT or mistargeting of this enzyme causes primary hyperoxaluria type 1, an inborn error of glyoxylate metabolism characterized by increased oxalate production | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
glyoxylate | pH 7.4, 37°C | Rattus norvegicus |  |
| 0.48 | - |
pyruvate | pH 7.4, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| cytoplasm | - |
Oryctolagus cuniculus | 5737 | - |
| cytoplasm | - |
Canis lupus familiaris | 5737 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Canis lupus familiaris | 5739 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
| peroxisome | - |
Oryctolagus cuniculus | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + pyruvate | Homo sapiens | L-serine metabolism | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Oryctolagus cuniculus | L-serine metabolism | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Canis lupus familiaris | L-serine metabolism | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Rattus norvegicus | gluconeogenesis from serine | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Oryctolagus cuniculus | gluconeogenesis from serine | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Canis lupus familiaris | gluconeogenesis from serine | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Homo sapiens | glyoxylate metabolism | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Rattus norvegicus | glyoxylate metabolism | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Rattus norvegicus Wistar | gluconeogenesis from serine | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | Rattus norvegicus Wistar | glyoxylate metabolism | 3-hydroxypyruvate + L-alanine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
dog | - |
| Homo sapiens | - |
human | - |
| Oryctolagus cuniculus | - |
rabbit, Japanese white | - |
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus Wistar | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + glyoxylate | - |
Homo sapiens | glycine + 3-hydroxypyruvate | - |
r | |
| L-serine + glyoxylate | - |
Rattus norvegicus | glycine + 3-hydroxypyruvate | - |
r | |
| L-serine + glyoxylate | - |
Canis lupus familiaris | glycine + 3-hydroxypyruvate | - |
r | |
| L-serine + glyoxylate | - |
Rattus norvegicus Wistar | glycine + 3-hydroxypyruvate | - |
r | |
| L-serine + pyruvate | - |
Homo sapiens | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | - |
Rattus norvegicus | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | - |
Oryctolagus cuniculus | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | - |
Canis lupus familiaris | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | L-serine metabolism | Homo sapiens | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | L-serine metabolism | Oryctolagus cuniculus | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | L-serine metabolism | Canis lupus familiaris | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | gluconeogenesis from serine | Rattus norvegicus | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | gluconeogenesis from serine | Oryctolagus cuniculus | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | gluconeogenesis from serine | Canis lupus familiaris | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | glyoxylate metabolism | Homo sapiens | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | glyoxylate metabolism | Rattus norvegicus | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | - |
Rattus norvegicus Wistar | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | gluconeogenesis from serine | Rattus norvegicus Wistar | 3-hydroxypyruvate + L-alanine | - |
r | |
| L-serine + pyruvate | glyoxylate metabolism | Rattus norvegicus Wistar | 3-hydroxypyruvate + L-alanine | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine:pyruvate/alanine:glyoxylate aminotransferase | - |
Homo sapiens |
| serine:pyruvate/alanine:glyoxylate aminotransferase | - |
Rattus norvegicus |
| serine:pyruvate/alanine:glyoxylate aminotransferase | - |
Oryctolagus cuniculus |
| serine:pyruvate/alanine:glyoxylate aminotransferase | - |
Canis lupus familiaris |
| SPT/AGT | - |
Homo sapiens |
| SPT/AGT | - |
Rattus norvegicus |
| SPT/AGT | - |
Oryctolagus cuniculus |
| SPT/AGT | - |
Canis lupus familiaris |
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