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Literature summary for 2.6.1.50 extracted from
- Enzymic synthesis of aminocyclitol moieties of aminoglycoside antibiotics from inositol by Streptomyces sp.: detection of glutamine-aminocyclitol aminotransferase and diaminocyclitol aminotransferase activities in a spectinomycin producer (1995), J. Bacteriol., 177, 818-822.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | 5'-hydroxystreptomycin production | Streptomyces griseocarneus |
| pharmacology | spectinomycin production | Streptomyces netropsis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | Streptomyces netropsis | - |
2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r |  |
| L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | Streptomyces hygroscopicus | - |
2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
| L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | Streptomyces griseocarneus | - |
2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces griseocarneus | - |
ATCC 12628 | - |
| Streptomyces hygroscopicus | - |
subsp. glebosus ATCC 14607 | - |
| Streptomyces netropsis | - |
ATCC 19756 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Streptomyces netropsis | - |
| mycelium | - |
Streptomyces hygroscopicus | - |
| mycelium | - |
Streptomyces griseocarneus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | - |
Streptomyces netropsis | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
| L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | - |
Streptomyces hygroscopicus | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
| L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | - |
Streptomyces griseocarneus | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
| myo-inositol + diaminocyclitol + oxaloacetate | - |
Streptomyces netropsis | amino-deoxyinositol + ketoaminocyclitol + malate | - |
r | |
| myo-inositol + diaminocyclitol + oxaloacetate | - |
Streptomyces hygroscopicus | amino-deoxyinositol + ketoaminocyclitol + malate | - |
r | |
| myo-inositol + glutamine + oxalacetate | - |
Streptomyces netropsis | amino-deoxyinositol + 2-oxoglutarate + malate + NH4+ | - |
r | |
| myo-inositol + glutamine + oxalacetate | - |
Streptomyces hygroscopicus | amino-deoxyinositol + 2-oxoglutarate + malate + NH4+ | - |
r | |
| N3-methyl-2-deoxy-streptamine + inosose | - |
Streptomyces netropsis | aminodeoxyinositol + 1-keto-2-deoxy-3-methylaminodeoxy-scyllo-inositol | - |
r | |
| N3-methyl-2-deoxy-streptamine + inosose | - |
Streptomyces hygroscopicus | aminodeoxyinositol + 1-keto-2-deoxy-3-methylaminodeoxy-scyllo-inositol | - |
r | |
| N3-methyl-2-deoxy-streptamine + inosose | - |
Streptomyces griseocarneus | aminodeoxyinositol + 1-keto-2-deoxy-3-methylaminodeoxy-scyllo-inositol | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L-glutamine:inosose aminotransferase | - |
Streptomyces netropsis |
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