Literature summary for 2.6.1.5 extracted from

Charfeddine, C.; Monastiri, K.; Mokni, M.; Laadjimi, A.; Kaabachi, N.; Perin, O.; Nilges, M.; Kassar, S.; Keirallah, M.; Guediche, M.N.; Kamoun, M.R.; Tebib, N.; Ben Dridi, M.F.; Boubaker, S.; Ben Osman, A.; Abdelhak, S.
Clinical and mutational investigations of tyrosinemia type II in Northern Tunisia: Identification and structural characterization of two novel TAT mutations (2006), Mol. Genet. Metab., 88, 184-191.

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Protein Variants

Protein Variants	Comment	Organism
C151Y	missense mutation leading to defective folding and likely alteration of the enzymatic activity	Homo sapiens
L273P	missense mutation leading to defective folding and likely alteration of the enzymatic activity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukocyte	-	Homo sapiens	-
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + 2-oxoglutarate	-	Homo sapiens	4-hydroxyphenylpyruvate + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
TATc	-	Homo sapiens
tyrosine aminotransferase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	dependent	Homo sapiens

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Release 2023.1 (January 2023)