Literature summary for 2.6.1.5 extracted from

Johansson, M.; Johansson, N.; Lund, B.O.
Xenobiotics and the glucocorticoid receptor: additive antagonistic effects on tyrosine aminotransferase activity in rat hepatoma cells (2005), Basic Clin. Pharmacol. Toxicol., 96, 309-315.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-methylsulfonyl-2,5,6,2',4',5'-hexachlorobiphenyl	significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0008 mM	Rattus norvegicus
4-methylsulfonyl-2,5,6,2',4'-pentachlorobiphenyl	significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0007 mM	Rattus norvegicus
ketoconazole	significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0011 mM	Rattus norvegicus
tolylfluanid	significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0014 mM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	induction of enzyme by dexamethasone	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H-II-E-C3 cell	Reuber hepatoma cell line	Rattus norvegicus	-

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Release 2023.1 (January 2023)