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Literature summary for 2.6.1.49 extracted from

  • Nagasaki, T.; Sugita, M.; Fukawa, H.
    Studies on DOPA transaminase of Alcaligenes faecalis (1973), Agric. Biol. Chem., 37, 1701-1706.
No PubMed abstract available
Search for more literature for 2.6.1.49

Inhibitors

Inhibitors Comment Organism Structure
Al3+ strong inhibition Alcaligenes faecalis
Co2+ weak inhibition Alcaligenes faecalis
Cu2+ strong inhibition Alcaligenes faecalis
Fe2+ strong inhibition Alcaligenes faecalis
Ni2+ inhibition of ADT and GDT, not PDT Alcaligenes faecalis
Zn2+ weak inhibition Alcaligenes faecalis

Organism

Organism UniProt Comment Textmining
Alcaligenes faecalis
-
 IAM 1015
-
Alcaligenes faecalis IAM 1015
-
 IAM 1015
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT Alcaligenes faecalis 3,4-dihydroxy-L-phenylalanine + oxaloacetate i.e. L-dopa ?
3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT Alcaligenes faecalis IAM 1015 3,4-dihydroxy-L-phenylalanine + oxaloacetate i.e. L-dopa ?
3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT Alcaligenes faecalis 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate i.e. L-dopa ?
3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT Alcaligenes faecalis IAM 1015 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate i.e. L-dopa ?
3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT Alcaligenes faecalis 3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate i.e. L-dopa ?
3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT Alcaligenes faecalis IAM 1015 3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate i.e. L-dopa ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
 15 min, complete loss of activity, enzyme GDT Alcaligenes faecalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 GDT Alcaligenes faecalis
9 10 ADT Alcaligenes faecalis
9.5
-
 PDT Alcaligenes faecalis

pH Stability

pH Stability pH Stability Maximum Comment Organism
8
-
 45°C, 30 min, enzyme GDT stable Alcaligenes faecalis
8.5 9 45°C, 30 min, enzyme PDT stable Alcaligenes faecalis