Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.44 extracted from

  • Sun, Y.; Li, W.; Shen, S.; Yang, X.; Lu, B.; Zhang, X.; Lu, P.; Shen, Y.; Ji, J.
    Loss of alanine-glyoxylate and serine-pyruvate aminotransferase expression accelerated the progression of hepatocellular carcinoma and predicted poor prognosis (2019), J. Transl. Med., 17, 390 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics loss of AGXT expression is correlated with a poor prognosis and differentiation of hepatocellular carcinoma (HCC) Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene AGXT, quantitative real-time reverse transcription-PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA enzyme knockdown in Huh-7 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + glyoxylate Homo sapiens
-
pyruvate + glycine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P21549
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
hepatoma cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-
additional information enzyme differential quantitative expression analysis in liver and hepatocellular carcinoma (data from 327 livers and 385 HCC tissues), overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + glyoxylate
-
Homo sapiens pyruvate + glycine
-
?
additional information the enzyme is also active as serine-pyruvate aminotransferase, EC 2.6.1.51 Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
AGXT
-
Homo sapiens
alanine-glyoxylate aminotransferase
-
Homo sapiens
More see also EC 2.6.1.51 Homo sapiens

General Information

General Information Comment Organism
malfunction critical role of AGXT deletion during HCC progression, loss of AGXT expression is correlated with a poor prognosis and differentiation of HCC. Loss of AGXT expression promotes the malignant phenotypes of HCC cell lines Homo sapiens
physiological function role of AGXT in hepatocellular carcinoma (HCC) progression with effects of AGXT on cell cycle and apoptosis in HCC cells. The proportions of both early apoptotic and late apoptotic/necrotic cells increase as the expression of AGXT decreases Homo sapiens