Application | Comment | Organism |
---|---|---|
diagnostics | loss of AGXT expression is correlated with a poor prognosis and differentiation of hepatocellular carcinoma (HCC) | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene AGXT, quantitative real-time reverse transcription-PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA enzyme knockdown in Huh-7 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + glyoxylate | Homo sapiens | - |
pyruvate + glycine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21549 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | enzyme differential quantitative expression analysis in liver and hepatocellular carcinoma (data from 327 livers and 385 HCC tissues), overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + glyoxylate | - |
Homo sapiens | pyruvate + glycine | - |
? | |
additional information | the enzyme is also active as serine-pyruvate aminotransferase, EC 2.6.1.51 | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AGXT | - |
Homo sapiens |
alanine-glyoxylate aminotransferase | - |
Homo sapiens |
More | see also EC 2.6.1.51 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | critical role of AGXT deletion during HCC progression, loss of AGXT expression is correlated with a poor prognosis and differentiation of HCC. Loss of AGXT expression promotes the malignant phenotypes of HCC cell lines | Homo sapiens |
physiological function | role of AGXT in hepatocellular carcinoma (HCC) progression with effects of AGXT on cell cycle and apoptosis in HCC cells. The proportions of both early apoptotic and late apoptotic/necrotic cells increase as the expression of AGXT decreases | Homo sapiens |