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Literature summary for 2.6.1.44 extracted from

  • Jarzebska, N.; Georgi, S.; Jabs, N.; Brilloff, S.; Maas, R.; Rodionov, R.N.; Zietz, C.; Montresor, S.; Hohenstein, B.; Weiss, N.
    Kidney and liver are the main organs of expression of a key metabolic enzyme alanine glyoxylate aminotransferase 2 in humans (2019), Atheroscler. Suppl., 40, 106-112 .
    View publication on PubMed
Search for more literature for 2.6.1.44

Cloned(Commentary)

Cloned (Comment) Organism
gene AGXT2, real-time RT-PCR enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Homo sapiens 31966
-
additional information AGXT2 RT-PCR expression analysis and immunohistochemic analysis in human tissues Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + glyoxylate Homo sapiens
-
 pyruvate + glycine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYV1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Homo sapiens
-
kidney convoluted tubule, strong AGXT2 expression is detected in proximal tubular epithelial cells Homo sapiens
-
liver diffuse AGXT2 expression in hepatocytes, but no significant AGXT2 expression in the hepatic vasculature Homo sapiens
-
additional information AGXT2 RT-PCR expression analysis and immunohistochemic analysis in human tissues, expression of key metabolic enzyme alanine:glyoxylate aminotransferase 2 in humans mainly in kidney and liver. The other tissues do not show any detectable AGXT2 mRNA Homo sapiens
-
renal proximal tubule epithelial cell
-
 Homo sapiens
-
small intestine very low content Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + glyoxylate
-
 Homo sapiens pyruvate + glycine
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, about, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
AGT2
-
 Homo sapiens
AGXT2
-
 Homo sapiens
alanine:glyoxylate aminotransferase 2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the endogenous inhibitor of nitric oxide synthases asymmetric dimethylarginine (ADMA) can be catabolized by dimethylarginine dimethylaminohydrolase (DDAH, EC 3.5.3.18) or metabolized through an alternative pathway by alanine:glyoxylate aminotransferase 2 (AGXT2) with the formation of 2-oxo-D-(N,N-dimethylguanidino)valeric acid (ADGV). AGXT2 can metabolize the cardiovascular risk factors N-monomethylarginine (NMMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) Homo sapiens