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Literature summary for 2.6.1.44 extracted from

  • Cellini, B.; Lorenzetto, A.; Montioli, R.; Oppici, E.; Voltattorni, C.B.
    Human liver peroxisomal alanine:glyoxylate aminotransferase: Different stability under chemical stress of the major allele, the minor allele, and its pathogenic G170R variant (2010), Biochimie, 92, 1801-1811.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
P11L one of the mutations of the minor allele Homo sapiens
P11L/I340M naturally occuring mutations, minor allele Homo sapiens
P11L/I340M/G170R naturally occuring mutations, pathogenic variant Homo sapiens

General Stability

General Stability Organism
major allele (P11/I340) is more stable against increasing urea concentrations than minor allele (P11L/I340M) or mutant protein P11L/I340M/G170R Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Renatured (Commentary)

Renatured (Comment) Organism
quick dilution (100fold) to an urea concentration that would be expected to support native enzyme, only about 20 and 5% of activity is recovered for major allele (P11/I340) and P11L/I340M (minor allele, respectively) Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Subunits

Subunits Comment Organism
homodimer gel filtration Homo sapiens

Synonyms

Synonyms Comment Organism
alanine:glyoxylate aminotransferase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens