Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
P11L | one of the mutations of the minor allele | Homo sapiens |
P11L/I340M | naturally occuring mutations, minor allele | Homo sapiens |
P11L/I340M/G170R | naturally occuring mutations, pathogenic variant | Homo sapiens |
General Stability | Organism |
---|---|
major allele (P11/I340) is more stable against increasing urea concentrations than minor allele (P11L/I340M) or mutant protein P11L/I340M/G170R | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Renatured (Comment) | Organism |
---|---|
quick dilution (100fold) to an urea concentration that would be expected to support native enzyme, only about 20 and 5% of activity is recovered for major allele (P11/I340) and P11L/I340M (minor allele, respectively) | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
homodimer | gel filtration | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
alanine:glyoxylate aminotransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |