Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F152A | the mutant shows decreased activity compared to the wild type enzyme | Homo sapiens |
F152I | the mutation is associated with primary hyperoxaluria type 1 in combination with the minor AGT allele and shows decreased activity compared to the wild type enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.22 | - |
glyoxylate | minor allele wild type enzyme | Homo sapiens | |
0.23 | - |
glyoxylate | major allele wild type enzyme | Homo sapiens | |
0.25 | - |
glyoxylate | minor allele mutant enzyme F152I | Homo sapiens | |
0.28 | - |
glyoxylate | major allele wild mutant enzyme F152I | Homo sapiens | |
0.34 | - |
glyoxylate | major allele wild mutant enzyme F152A | Homo sapiens | |
28 | - |
L-alanine | minor allele wild type enzyme | Homo sapiens | |
31 | - |
L-alanine | major allele wild type enzyme | Homo sapiens | |
37 | - |
L-alanine | major allele mutant enzyme F152I | Homo sapiens | |
41 | - |
L-alanine | minor allele mutant enzyme F152I | Homo sapiens | |
46 | - |
L-alanine | major allele mutant enzyme F152A | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21549 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + glyoxylate | - |
Homo sapiens | pyruvate + glycine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGT | - |
Homo sapiens |
AGT-Ma | major allele of alanine:glyoxylate aminotransferase | Homo sapiens |
AGT-Mi | minor allele of alanine:glyoxylate aminotransferase | Homo sapiens |
alanine:glyoxylate aminotransferase | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
70.1 | - |
the melting temperature of the minor allele holoenzyme is at 70.1°C | Homo sapiens |
76.3 | - |
the melting temperature of the major allele holoenzyme is at 76.3°C | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21.2 | - |
L-alanine | major allele mutant enzyme F152A | Homo sapiens | |
22.6 | - |
glyoxylate | major allele wild mutant enzyme F152A | Homo sapiens | |
33 | - |
L-alanine | minor allele wild type enzyme | Homo sapiens | |
33.6 | - |
L-alanine | minor allele mutant enzyme F152I | Homo sapiens | |
35 | - |
L-alanine | major allele mutant enzyme F152I | Homo sapiens | |
37 | - |
glyoxylate | minor allele wild type enzyme | Homo sapiens | |
39 | - |
glyoxylate | major allele wild mutant enzyme F152I | Homo sapiens | |
40 | - |
glyoxylate | minor allele mutant enzyme F152I | Homo sapiens | |
45 | - |
glyoxylate | major allele wild type enzyme | Homo sapiens | |
45 | - |
L-alanine | major allele wild type enzyme | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | alanine:glyoxylate aminotransferase deficiency causes primary hyperoxaluria type 1 | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.46 | - |
L-alanine | major allele mutant enzyme F152A | Homo sapiens | |
0.82 | - |
L-alanine | minor allele mutant enzyme F152I | Homo sapiens | |
0.95 | - |
L-alanine | major allele mutant enzyme F152I | Homo sapiens | |
1.2 | - |
L-alanine | minor allele wild type enzyme | Homo sapiens | |
1.4 | - |
L-alanine | major allele wild type enzyme | Homo sapiens | |
66 | - |
glyoxylate | major allele wild mutant enzyme F152A | Homo sapiens | |
139 | - |
glyoxylate | major allele wild mutant enzyme F152I | Homo sapiens | |
160 | - |
glyoxylate | minor allele mutant enzyme F152I | Homo sapiens | |
168 | - |
glyoxylate | minor allele wild type enzyme | Homo sapiens | |
196 | - |
glyoxylate | major allele wild type enzyme | Homo sapiens |