BRENDA - Enzyme Database
show all sequences of 2.6.1.44

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

Cellini, B.; Bertoldi, M.; Montioli, R.; Paiardini, A.; Borri Voltattorni, C.; Biochem. J. 408, 39-50 (2007)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Escherichia coli; wild-type and G82E mutant His-tagged enzyme expressed in Escherichia coli
Homo sapiens
Engineering
Protein Variants
Commentary
Organism
G82E
natural enzyme variant. Significant reduction in affinty for pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate. Mutant displays an altered conformational state of the bound pyridoxal 5'-phosphate and a decrease in overall catlytic activity to 0.1% of wild-type; naturally occuring variant. Like the wild-type, the G82E variant is able to bind 2 mol pyridoxal 5'-phosphate/dimer, it exhibits a significant reduced affinity for pyridoxal 5'-phosphate and even more for pyridoxamine 5'-phosphate compared with wild-type, and an altered conformational state of the bound pyridoxal 5'-phosphate. Dramatic decrease of the overall catalytic activity (about 0.1% of that of normal alanine:glyoxylate aminotransferase), appears to be related to the inability to undergo an efficient transaldimination of the pyridoxal 5'-phosphate form of the enzyme with amino acids as well as an efficient conversion of AGT-pyridoxamine 5'-phosphate into AGT-pyridoxal 5'-phosphate
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
D-alanine
competitive inhibitor with L-alanine as varied substrate and glyoxylate as fixed substrate. Uncompetitive inhibitor with glyoxylate as varied substrate and L-alanine as fixed substrate; competitive with L-alanine, uncompetitive with glyoxylate
Homo sapiens
pyruvate
mixed type inhibition with L-alanine, competitive with glyoxylate; mixed type inhibitor with L-alanine as varied substrate and glyoxylate as fixed substrate. Competitive inhibitor with glyoxylate as varied substrate and L-alanine as fixed substrate
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.15
-
glyoxylate
mutant G82E, 25°C; pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
0.21
-
pyruvate
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
0.23
-
glyoxylate
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
15
-
L-alanine
mutant G82E, 25°C; pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
22
-
glycine
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
31
-
L-alanine
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-alanine + glyoxylate
Homo sapiens
the enzyme is highly specific for catalysing glyoxylate to glycine processing, thereby playing a key role in glyoxylate detoxification
pyruvate + glycine
-
-
?
additional information
Homo sapiens
enzyme is highly specific for catalyzing glyoxylate to glycine processing, playing a key role in glyoxylate detoxification
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
A2V838
-
-
Homo sapiens
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
recombinant wild-type and G82E mutant His-tagged enzyme
Homo sapiens
Reaction
Reaction
Commentary
Organism
Reaction ID
L-alanine + glyoxylate = pyruvate + glycine
pyridoxamine 5'-phosphate remains bound to the enzyme during the catalytic cycle. The enzyme-pyridoxamine 5'-phosphate complex displays a reactivity towards oxo acids higher than that of the apo-enzyme in presence of pyridoxamine
Homo sapiens
Storage Stability
Storage Stability
Organism
-20°C, wild-type and mutant enzyme G82E are stable for at least 1 month
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
glycine + pyruvate
-
684989
Homo sapiens
L-alanine + glyoxylate
-
-
-
?
L-alanine + glyoxylate
the enzyme is highly specific for catalysing glyoxylate to glycine processing, thereby playing a key role in glyoxylate detoxification
684989
Homo sapiens
pyruvate + glycine
-
-
-
?
L-alanine + glyoxylate
the enzyme is highly specific for catalysing glyoxylate to glycine processing
684989
Homo sapiens
pyruvate + glycine
-
-
-
?
L-alanine + glyoxylate
transamination half-reaction kinetic parameters
684989
Homo sapiens
glycine + pyruvate
-
-
-
r
L-arginine + pyruvate
-
684989
Homo sapiens
5-guanidino-2-oxopentanoate + L-alanine
-
-
-
?
L-asparagine + glyoxylate
-
684989
Homo sapiens
4-amino-2,4-dioxobutanoate + glycine
-
-
-
?
L-glutamate + glyoxylate
-
684989
Homo sapiens
2-oxoglutaramate + glycine
-
-
-
?
L-phenylalanine + glyoxylate
-
684989
Homo sapiens
phenylpyruvate + glycine
-
-
-
?
L-serine + glyoxylate
-
684989
Homo sapiens
3-hydroxy-2-oxopropanoate + glycine
-
-
-
?
additional information
enzyme is highly specific for catalyzing glyoxylate to glycine processing, playing a key role in glyoxylate detoxification
684989
Homo sapiens
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
AGT
-
Homo sapiens
alanine:glyoxylate aminotransferase
-
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.068
-
glyoxylate
mutant G82E, 25°C; pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
0.07
-
L-alanine
mutant G82E, 25°C; pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
0.33
-
glycine
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
0.36
-
pyruvate
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
45
-
glyoxylate
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
45
-
L-alanine
pH 7.4, 25°C, wild-type enzyme; wild-type, 25°C
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
like the wild-type, the G82E variant is able to bind 2 mol pyridoxal 5'-phosphate/dimer, it exhibits a significant reduced affinity for pyridoxal 5'-phosphate and even more for pyridoxamine 5'-phosphate compared with wild-type, and an altered conformational state of the bound pyridoxal 5'-phosphate
Homo sapiens
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.3
-
pyruvate
glyoxylate as varied substrate and L-alanine as fixed substrate
Homo sapiens
14.3
-
D-alanine
with L-alanine as varied substrate and glyoxylate as fixed substrate, Kis
Homo sapiens
15.8
-
pyruvate
with L-alanine as varied substrate and glyoxylate as fixed substrate, Kis
Homo sapiens
22.8
-
pyruvate
with L-alanine as varied substrate and glyoxylate as fixed substrate, Kii
Homo sapiens
28.7
-
D-alanine
with glyoxylate as varied substrate and L-alanine as fixed substrate, Kii
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
wild-type and G82E mutant His-tagged enzyme expressed in Escherichia coli
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
like the wild-type, the G82E variant is able to bind 2 mol pyridoxal 5'-phosphate/dimer, it exhibits a significant reduced affinity for pyridoxal 5'-phosphate and even more for pyridoxamine 5'-phosphate compared with wild-type, and an altered conformational state of the bound pyridoxal 5'-phosphate
Homo sapiens
Engineering (protein specific)
Protein Variants
Commentary
Organism
G82E
natural enzyme variant. Significant reduction in affinty for pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate. Mutant displays an altered conformational state of the bound pyridoxal 5'-phosphate and a decrease in overall catlytic activity to 0.1% of wild-type
Homo sapiens
G82E
naturally occuring variant. Like the wild-type, the G82E variant is able to bind 2 mol pyridoxal 5'-phosphate/dimer, it exhibits a significant reduced affinity for pyridoxal 5'-phosphate and even more for pyridoxamine 5'-phosphate compared with wild-type, and an altered conformational state of the bound pyridoxal 5'-phosphate. Dramatic decrease of the overall catalytic activity (about 0.1% of that of normal alanine:glyoxylate aminotransferase), appears to be related to the inability to undergo an efficient transaldimination of the pyridoxal 5'-phosphate form of the enzyme with amino acids as well as an efficient conversion of AGT-pyridoxamine 5'-phosphate into AGT-pyridoxal 5'-phosphate
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
D-alanine
competitive with L-alanine, uncompetitive with glyoxylate
Homo sapiens
D-alanine
competitive inhibitor with L-alanine as varied substrate and glyoxylate as fixed substrate. Uncompetitive inhibitor with glyoxylate as varied substrate and L-alanine as fixed substrate
Homo sapiens
pyruvate
mixed type inhibition with L-alanine, competitive with glyoxylate
Homo sapiens
pyruvate
mixed type inhibitor with L-alanine as varied substrate and glyoxylate as fixed substrate. Competitive inhibitor with glyoxylate as varied substrate and L-alanine as fixed substrate
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.3
-
pyruvate
glyoxylate as varied substrate and L-alanine as fixed substrate
Homo sapiens
14.3
-
D-alanine
with L-alanine as varied substrate and glyoxylate as fixed substrate, Kis
Homo sapiens
15.8
-
pyruvate
with L-alanine as varied substrate and glyoxylate as fixed substrate, Kis
Homo sapiens
22.8
-
pyruvate
with L-alanine as varied substrate and glyoxylate as fixed substrate, Kii
Homo sapiens
28.7
-
D-alanine
with glyoxylate as varied substrate and L-alanine as fixed substrate, Kii
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.15
-
glyoxylate
mutant G82E, 25°C
Homo sapiens
0.15
-
glyoxylate
pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
0.21
-
pyruvate
wild-type, 25°C
Homo sapiens
0.21
-
pyruvate
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
0.23
-
glyoxylate
wild-type, 25°C
Homo sapiens
0.23
-
glyoxylate
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
15
-
L-alanine
mutant G82E, 25°C
Homo sapiens
15
-
L-alanine
pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
22
-
glycine
wild-type, 25°C
Homo sapiens
22
-
glycine
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
31
-
L-alanine
wild-type, 25°C
Homo sapiens
31
-
L-alanine
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-alanine + glyoxylate
Homo sapiens
the enzyme is highly specific for catalysing glyoxylate to glycine processing, thereby playing a key role in glyoxylate detoxification
pyruvate + glycine
-
-
?
additional information
Homo sapiens
enzyme is highly specific for catalyzing glyoxylate to glycine processing, playing a key role in glyoxylate detoxification
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant wild-type and G82E mutant His-tagged enzyme
Homo sapiens
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, wild-type and mutant enzyme G82E are stable for at least 1 month
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
glycine + pyruvate
-
684989
Homo sapiens
L-alanine + glyoxylate
-
-
-
?
L-alanine + glyoxylate
the enzyme is highly specific for catalysing glyoxylate to glycine processing, thereby playing a key role in glyoxylate detoxification
684989
Homo sapiens
pyruvate + glycine
-
-
-
?
L-alanine + glyoxylate
the enzyme is highly specific for catalysing glyoxylate to glycine processing
684989
Homo sapiens
pyruvate + glycine
-
-
-
?
L-alanine + glyoxylate
transamination half-reaction kinetic parameters
684989
Homo sapiens
glycine + pyruvate
-
-
-
r
L-arginine + pyruvate
-
684989
Homo sapiens
5-guanidino-2-oxopentanoate + L-alanine
-
-
-
?
L-asparagine + glyoxylate
-
684989
Homo sapiens
4-amino-2,4-dioxobutanoate + glycine
-
-
-
?
L-glutamate + glyoxylate
-
684989
Homo sapiens
2-oxoglutaramate + glycine
-
-
-
?
L-phenylalanine + glyoxylate
-
684989
Homo sapiens
phenylpyruvate + glycine
-
-
-
?
L-serine + glyoxylate
-
684989
Homo sapiens
3-hydroxy-2-oxopropanoate + glycine
-
-
-
?
additional information
enzyme is highly specific for catalyzing glyoxylate to glycine processing, playing a key role in glyoxylate detoxification
684989
Homo sapiens
?
-
-
-
-
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.068
-
glyoxylate
mutant G82E, 25°C
Homo sapiens
0.068
-
glyoxylate
pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
0.07
-
L-alanine
mutant G82E, 25°C
Homo sapiens
0.07
-
L-alanine
pH 7.4, 25°C, mutant enzyme G82E
Homo sapiens
0.33
-
glycine
wild-type, 25°C
Homo sapiens
0.33
-
glycine
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
0.36
-
pyruvate
wild-type, 25°C
Homo sapiens
0.36
-
pyruvate
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
45
-
glyoxylate
wild-type, 25°C
Homo sapiens
45
-
glyoxylate
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
45
-
L-alanine
wild-type, 25°C
Homo sapiens
45
-
L-alanine
pH 7.4, 25°C, wild-type enzyme
Homo sapiens
Other publictions for EC 2.6.1.44
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737777
Fargue
Effects of alanine:glyoxylate ...
Homo sapiens
Biochim. Biophys. Acta
1862
1055-1062
2016
-
2
-
-
-
-
-
-
-
-
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-
1
-
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-
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1
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2
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-
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-
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-
-
-
-
-
-
-
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-
737947
Abe
Distribution of D-3-aminoisobu ...
Rattus norvegicus
BMC Neurosci.
15
53
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
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2
-
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1
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2
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
739170
Rodionov
Role of alanine:glyoxylate ami ...
Mus musculus
Nephrol. Dial. Transplant.
29
2035-2042
2014
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
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1
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-
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-
722812
Fargue
Four of the most common mutati ...
Homo sapiens
J. Biol. Chem.
288
2475-2484
2013
-
-
1
-
5
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737740
Oppici
Gly161 mutations associated wi ...
Homo sapiens
Biochim. Biophys. Acta
1832
2277-2288
2013
-
1
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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1
1
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3
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
739610
Oppici
Crystal structure of the S187F ...
Homo sapiens
Proteins
81
1457-1465
2013
-
-
-
1
1
-
-
2
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
1
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
721240
Kawai
A novel mutation of human live ...
Homo sapiens
Acta Histochem. Cytochem.
45
121-129
2012
-
-
1
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
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1
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2
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721464
Caplin
Alanine-glyoxylate aminotransf ...
Mus musculus
Arterioscler. Thromb. Vasc. Biol.
32
2892-2900
2012
-
-
1
-
-
-
-
-
1
-
-
-
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1
-
-
-
-
-
1
-
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1
-
2
-
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-
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1
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1
-
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1
-
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
722393
Montioli
The N-terminal extension is es ...
Homo sapiens
Int. J. Biochem. Cell Biol.
44
536-546
2012
-
-
1
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
-
-
1
-
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-
-
-
1
1
-
2
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Coulter-Mackie
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Cellini
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Cellini
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Ricoult
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Coulter-Mackie
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Salido
Alanine-glyoxylate aminotransf ...
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Meyer
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Coulter-Mackie
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Coulter-Mackie
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Koul
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Huber
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2
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1
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2
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3
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1
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2
2
1
-
2
-
1
-
-
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-
-
663449
Schlosser
Alanine:glyoxylate aminotransf ...
Saccharomyces cerevisiae
Yeast
21
63-73
2004
-
-
-
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1
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4
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640086
Danpure
Alanine:glyoxylate aminotransf ...
Homo sapiens
Biochim. Biophys. Acta
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2003
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1
1
1
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1
1
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640087
Santana
Primary hyperoxaluria type 1 i ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
100
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2003
-
1
1
-
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1
2
1
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1
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4
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1
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1
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1
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1
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1
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2
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-
-
-
-
-
640088
Zhang
Crystal structure of alanine:g ...
Homo sapiens
J. Mol. Biol.
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2003
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1
-
1
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1
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
662732
Nishijima
Hepatic alanine-glyoxylate ami ...
Rattus norvegicus
J. Urol.
169
683-686
2003
-
1
-
-
-
-
-
-
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3
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1
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1
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1
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-
-
-
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-
-
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-
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-
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-
663117
Liepman
Alanine aminotransferase homol ...
Arabidopsis thaliana
Plant Physiol.
131
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2003
-
-
-
-
-
-
-
8
1
-
2
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2
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5
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4
1
2
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8
2
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2
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8
-
-
4
2
-
-
-
-
-
-
-
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-
-
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640085
Han
Comparative characterization o ...
Aedes aegypti, Drosophila melanogaster
FEBS Lett.
527
199-204
2002
-
-
2
-
-
-
-
6
-
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2
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6
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35
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2
2
2
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4
4
2
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2
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6
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2
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-
-
35
-
2
2
-
4
4
2
-
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-
-
-
-
-
-
640083
Liepman
Peroxisomal alanine: glyoxylat ...
Arabidopsis thaliana
Plant J.
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2001
-
-
1
-
-
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-
3
2
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3
1
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6
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1
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2
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4
1
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1
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1
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2
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3
1
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1
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2
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4
1
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-
-
-
-
-
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-
-
-
-
640084
Zhang
Crystallization and preliminar ...
Homo sapiens
Acta Crystallogr. Sect. D
57
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2001
-
1
1
1
-
-
-
-
-
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1
1
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1
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1
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1
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1
1
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1
1
1
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1
1
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1
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1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640080
Holbrook
Molecular adaptation of alanin ...
Ateles paniscus, Callimico goeldii, Callithrix jacchus, Cercopithecus diana, Cheirogaleus medius, Eulemur fulvus, Gorilla gorilla, Homo sapiens, Hylobates lar, Leontopithecus rosalia, Loris tardigradus, Macaca fuscata, Macaca nigra, Mico argentatus, Nycticebus pygmaeus, Pan troglodytes, Papio anubis, Pithecia pithecia, Pongo pygmaeus, Saguinus oedipus, Saimiri sciureus
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12
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21
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21
-
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12
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-
21
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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640081
Lumb
Functional synergism between t ...
Homo sapiens
J. Biol. Chem.
275
36415-36422
2000
-
1
1
-
-
-
-
4
1
-
1
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-
1
-
-
1
-
-
1
1
-
-
1
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-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
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-
-
-
4
1
-
1
-
-
-
-
1
-
1
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640082
Oda
Mitochondrial targeting signal ...
Rattus norvegicus
J. Biochem.
127
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2000
-
-
1
-
-
-
-
-
4
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1
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2
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1
-
-
2
-
-
-
1
1
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
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4
-
1
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640079
Rumsby
-
A semiautomated alanine:glyoxy ...
Homo sapiens
Ann. Clin. Biochem.
34
400-404
1997
-
1
-
-
-
-
-
2
1
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
640077
Ishikawa
Pyridoxal 5'-phosphate binding ...
Rattus norvegicus
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119
970-978
1996
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
1
-
-
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640078
Leiper
Inhibition of alanine:glyoxyla ...
Homo sapiens
J. Cell. Biol.
135
939-951
1996
-
1
1
-
-
-
-
-
1
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2
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1
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-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640076
Horvath
Aminooxy acetic acid: a select ...
Homo sapiens
Clin. Chim. Acta
243
105-114
1995
-
1
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640075
Danpure
Cytosolic compartmentalization ...
Homo sapiens
J. Inherit. Metab. Dis.
17
27-40
1994
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1
1
-
-
-
-
-
2
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1
1
-
1
-
-
1
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
2
-
1
1
-
-
-
1
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640074
Sakuraba
Purification and characterizat ...
Anas platyrhynchos domestica, Anser anser domesticus, Columba livia, Gallus gallus, Melopsittacus undulatus, Padda oryzivora, Passer montanus saturatus, Phasianus versicolor, Serinus canaria, Uroloncha striata domestica
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286
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1991
-
-
-
-
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1
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11
-
7
2
-
16
-
-
2
-
-
11
1
4
2
4
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
11
-
7
2
-
-
-
2
-
11
1
4
2
4
-
-
-
-
2
-
-
-
-
-
-
-
-
-
640073
Kobayashi
Identity of alanine:glyoxylate ...
Rattus norvegicus
Biochimie
71
471-475
1989
-
-
-
-
-
-
-
-
4
-
3
-
-
2
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
4
-
3
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
640072
Okuno
Alanine:glyoxylate aminotransf ...
Suncus murinus
Comp. Biochem. Physiol. B
90
773-778
1988
-
-
-
-
-
-
1
3
-
-
1
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
3
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640071
Takada
Characteristics of alanine: gl ...
Saccharomyces cerevisiae
Biochem. J.
231
157-163
1985
-
-
-
-
-
-
4
2
-
-
2
1
-
3
-
-
1
-
-
-
1
2
3
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
1
-
-
-
-
4
-
2
-
-
2
1
-
-
-
1
-
-
1
2
3
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
640070
Noguchi
Enzymatic and immunological co ...
Caranx chrysos, Sardinops sp., Scomberomorus sp., Sebastes carnatus
Comp. Biochem. Physiol. B
77
279-283
1984
-
-
-
-
-
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-
-
-
-
1
1
-
4
-
-
4
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
4
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640069
Nakamura
Serine: glyoxylate, alanine:gl ...
Spinacia oleracea
J. Biol. Chem.
258
7631-7638
1983
-
-
-
-
-
-
3
3
1
-
-
1
-
1
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-
-
-
-
1
-
1
2
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
2
3
1
-
-
1
-
-
-
-
-
1
-
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640068
Okuno
Co-purification of alanine-gly ...
Rattus norvegicus
Biochim. Biophys. Acta
715
97-104
1982
-
-
-
-
-
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8
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5
1
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2
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1
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3
1
3
8
1
2
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1
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1
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8
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5
1
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1
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3
1
3
8
1
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-
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-
-
-
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640067
Noguchi
Characteristics of hepatic ala ...
Canis lupus familiaris, Felis catus, Mus musculus, Rattus norvegicus
Biochem. J.
169
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1978
4
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12
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15
4
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8
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8
8
8
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4
1
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6
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2
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4
-
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-
-
-
10
-
12
5
-
15
4
-
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4
-
8
8
8
44
4
-
-
-
-
6
-
-
2
-
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-
-
-
636593
Koide
-
L-alanine-alpha-keto acid amin ...
Pseudomonas sp.
Agric. Biol. Chem.
41
781-784
1977
-
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-
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1
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1
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-
-
-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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640065
Rowsell
The subcellular distribution o ...
Rattus norvegicus
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127
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1972
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-
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1
2
3
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-
-
-
2
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-