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Literature summary for 2.6.1.44 extracted from

  • Santana, A.; Salido, E.; Torres, A.; Shapiro, L.J.
    Primary hyperoxaluria type 1 in the Canary Islands: A conformational disease due to I244T mutation in the P11L-containing alanine:glyoxylate aminotransferase (2003), Proc. Natl. Acad. Sci. USA, 100, 7277-7282.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
AGXT cDNA cloned, AGXT*LTM expressed as a GST-fusion protein in Escherichia coli BL21(RIL) and in Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
amino-oxyacetic acid
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.36
-
glyoxylate pH 7.4, 37°C, alanine as amino donor Homo sapiens
14.9
-
L-alanine pH 7.4, 37°C, glyoxylate as amino acceptor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + glyoxylate Homo sapiens key role in the transamination/detoxification of glyoxylate pyruvate + glycine
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + glyoxylate
-
Homo sapiens pyruvate + glycine
-
ir
L-alanine + glyoxylate key role in the transamination/detoxification of glyoxylate Homo sapiens pyruvate + glycine
-
ir

Synonyms

Synonyms Comment Organism
AGXT
-
Homo sapiens