BRENDA - Enzyme Database
show all sequences of 2.6.1.44

Characteristics of hepatic alanine-glyoxylate aminotransferase in different mammalian species

Noguchi, T.; Okuno, E.; Takada, Y.; Minatogawa, Y.; Okai, K.; Kido, R.; Biochem. J. 169, 113-122 (1978)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
glucagon
induced by, isoenzyme 1 is increased in activity
Canis lupus familiaris
glucagon
induced by, isoenzyme 1 is increased in activity
Felis catus
glucagon
induced by, isoenzyme 1 is increased in activity
Mus musculus
glucagon
induced by, isoenzyme 1 is increased in activity
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
hydroxylamine
isoenzyme 1
Canis lupus familiaris
hydroxylamine
isoenzyme 1
Felis catus
hydroxylamine
isoenzyme; isoenzyme 1
Mus musculus
hydroxylamine
isoenzyme; isoenzyme 1
Rattus norvegicus
Isonicotinic acid hydrazide
isoenzyme 1 and isoenzyme 2
Mus musculus
Isonicotinic acid hydrazide
isoenzyme 1 and isoenzyme 2
Rattus norvegicus
Semicarbazide
isoenzyme 1
Canis lupus familiaris
Semicarbazide
isoenzyme 1
Felis catus
Semicarbazide
isoenzyme; isoenzyme 1
Mus musculus
Semicarbazide
isoenzyme; isoenzyme 1
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.07
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Rattus norvegicus
0.1
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Felis catus
0.13
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Canis lupus familiaris
0.2
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Mus musculus
0.72
-
glyoxylate
pH 8.0, 37C, alanine as amino donor
Mus musculus
1
-
glyoxylate
pH 8.2, 37C, isoenzyme 2, alanine as amino donor
Rattus norvegicus
1.4
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Mus musculus
2.1
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Rattus norvegicus
3
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Canis lupus familiaris
3.9
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Canis lupus familiaris
25
-
L-alanine
pH 8.2, 37C, isoenzyme 2, glyoxylate as amino acceptor
Mus musculus
30
-
L-alanine
pH 8.2, 37C, isoenzyme 2, glyoxylate as amino acceptor
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Canis lupus familiaris
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Felis catus
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Mus musculus
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Rattus norvegicus
77000
-
-
Canis lupus familiaris
77000
-
-
Felis catus
77000
-
-
Mus musculus
77000
-
isoenzyme 1, gel filtration
Rattus norvegicus
80000
-
sucrose-density-gradient centrifugation
Canis lupus familiaris
80000
-
sucrose-density-gradient centrifugation
Felis catus
80000
-
sucrose-density-gradient centrifugation
Mus musculus
80000
-
peroxisomal and mitochondrial alanine-glyoxylate aminotransferase 1; sucrose-density-gradient centrifugation
Rattus norvegicus
170000
-
isoenzyme 2, gel filtration
Rattus norvegicus
175000
-
-
Canis lupus familiaris
175000
-
liver isoenzyme 2, gel filtration
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-alanine + glyoxylate
Mus musculus
-
pyruvate + glycine
-
Mus musculus
ir
L-alanine + glyoxylate
Rattus norvegicus
-
pyruvate + glycine
-
Rattus norvegicus
ir
L-alanine + glyoxylate
Canis lupus familiaris
-
pyruvate + glycine
-
Canis lupus familiaris
ir
L-alanine + glyoxylate
Felis catus
-
pyruvate + glycine
-
Felis catus
ir
Organism
Organism
UniProt
Commentary
Textmining
Canis lupus familiaris
-
dog
-
Felis catus
-
cat
-
Mus musculus
-
mouse
-
Rattus norvegicus
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
isoenzyme 1
Canis lupus familiaris
isoenzyme 1
Felis catus
isoenzyme 1 and 2
Mus musculus
isoenzyme 1 and 2
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
liver
-
Canis lupus familiaris
-
liver
-
Felis catus
-
liver
-
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
2.64
-
isoenzyme 2
Canis lupus familiaris
2.93
-
isoenzyme 2
Canis lupus familiaris
2.93
-
-
Rattus norvegicus
21.4
-
isoenzyme 1
Rattus norvegicus
23.2
-
isoenzyme 1
Mus musculus
86.3
-
isoenzyme 1
Felis catus
91
-
isoenzyme 1
Canis lupus familiaris
160
-
isoenzyme 1
Rattus norvegicus
Storage Stability
Storage Stability
Organism
-20C, 50 mM potassium phosphate buffer, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Rattus norvegicus
-20C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Mus musculus
-20C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Canis lupus familiaris
-20C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Felis catus
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Mus musculus
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Rattus norvegicus
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Canis lupus familiaris
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Felis catus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
L-alanine + glyoxylate
-
640067
Mus musculus
pyruvate + glycine
-
640067
Mus musculus
ir
L-alanine + glyoxylate
-
640067
Rattus norvegicus
pyruvate + glycine
-
640067
Rattus norvegicus
ir
L-alanine + glyoxylate
-
640067
Canis lupus familiaris
pyruvate + glycine
-
640067
Canis lupus familiaris
ir
L-alanine + glyoxylate
-
640067
Felis catus
pyruvate + glycine
-
640067
Felis catus
ir
L-alanine + glyoxylate
isoenzyme 1
640067
Mus musculus
pyruvate + glycine
-
640067
Mus musculus
ir
L-alanine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
pyruvate + glycine
-
640067
Rattus norvegicus
ir
L-alanine + glyoxylate
isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors
640067
Mus musculus
pyruvate + glycine
-
640067
Mus musculus
ir
L-alanine + glyoxylate
isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors
640067
Rattus norvegicus
pyruvate + glycine
-
640067
Rattus norvegicus
ir
L-alanine + hydroxypyruvate
-
640067
Canis lupus familiaris
pyruvate + L-serine
-
-
-
ir
L-alanine + hydroxypyruvate
-
640067
Felis catus
pyruvate + L-serine
-
-
-
ir
L-alanine + hydroxypyruvate
isoenzyme 1
640067
Mus musculus
pyruvate + L-serine
-
-
-
ir
L-alanine + hydroxypyruvate
isoenzyme 1
640067
Rattus norvegicus
pyruvate + L-serine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1
640067
Mus musculus
pyruvate + L-phenylalanine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1
640067
Rattus norvegicus
pyruvate + L-phenylalanine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1, less effectively acceptor
640067
Canis lupus familiaris
pyruvate + L-phenylalanine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1, less effectively acceptor
640067
Felis catus
pyruvate + L-phenylalanine
-
-
-
ir
L-asparagine + glyoxylate
isoenzyme 1
640067
Mus musculus
4-amino-2,4-dioxobutanoate + glycine
-
-
-
ir
L-asparagine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
4-amino-2,4-dioxobutanoate + glycine
-
-
-
ir
L-glutamine + glyoxylate
isoenzyme 1
640067
Mus musculus
2-oxoglutaramate + glycine
-
-
-
ir
L-glutamine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
2-oxoglutaramate + glycine
-
-
-
ir
L-histidine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
ir
L-histidine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
ir
L-isoleucine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-methyl-2-oxopropanoate + glycine
-
-
-
ir
L-leucine + glyoxylate
isoenzyme 1
640067
Mus musculus
4-methyl-2-oxopentanoate + glycine
-
-
-
ir
L-leucine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
4-methyl-2-oxopentanoate + glycine
-
-
-
ir
L-methionine + glyoxylate
isoenzyme 1
640067
Mus musculus
4-methylsulfanyl-2-oxobutanoate + glycine
-
-
-
ir
L-methionine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
4-methylsulfanyl-2-oxobutanoate + glycine
-
-
-
ir
L-phenylalanine + glyoxylate
isoenzyme 1
640067
Mus musculus
phenylpyruvate + glycine
-
-
-
ir
L-phenylalanine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
phenylpyruvate + glycine
-
-
-
ir
L-serine + glyoxylate
-
640067
Canis lupus familiaris
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
-
640067
Felis catus
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Mus musculus
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Rattus norvegicus
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Canis lupus familiaris
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Felis catus
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-tyrosine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
ir
L-tyrosine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
ir
L-valine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-methyl-2-oxobutanoate + glycine
-
-
-
ir
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Mus musculus
?
-
-
-
-
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Rattus norvegicus
?
-
-
-
-
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Canis lupus familiaris
?
-
-
-
-
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Felis catus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Canis lupus familiaris
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Felis catus
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Mus musculus
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Rattus norvegicus
Synonyms
Synonyms
Commentary
Organism
EC 2.6.1.51
serine-pyruvate aminotransferase identical with liver isoenzyme 1
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.1
8.4
isoenzyme 2
Mus musculus
8.3
8.6
-
Canis lupus familiaris
8.3
8.6
-
Felis catus
8.3
8.6
-
Mus musculus
8.3
8.6
-
Rattus norvegicus
8.5
8.8
isoenzyme 2
Rattus norvegicus
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Mus musculus
isoelectric focusing on a pH 3.5-10 ampholine gradient
-
5.9
Rattus norvegicus
isoelectric focusing on a pH 3.5-10 ampholine gradient
-
6
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
glucagon
induced by, isoenzyme 1 is increased in activity
Canis lupus familiaris
glucagon
induced by, isoenzyme 1 is increased in activity
Felis catus
glucagon
induced by, isoenzyme 1 is increased in activity
Mus musculus
glucagon
induced by, isoenzyme 1 is increased in activity
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
hydroxylamine
isoenzyme 1
Canis lupus familiaris
hydroxylamine
isoenzyme 1
Felis catus
hydroxylamine
isoenzyme; isoenzyme 1
Mus musculus
hydroxylamine
isoenzyme; isoenzyme 1
Rattus norvegicus
Isonicotinic acid hydrazide
isoenzyme 1 and isoenzyme 2
Mus musculus
Isonicotinic acid hydrazide
isoenzyme 1 and isoenzyme 2
Rattus norvegicus
Semicarbazide
isoenzyme 1
Canis lupus familiaris
Semicarbazide
isoenzyme 1
Felis catus
Semicarbazide
isoenzyme; isoenzyme 1
Mus musculus
Semicarbazide
isoenzyme; isoenzyme 1
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.07
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Rattus norvegicus
0.1
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Felis catus
0.13
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Canis lupus familiaris
0.2
-
glyoxylate
pH 8.2, 37C, isoenzyme 1, alanine as amino donor
Mus musculus
0.72
-
glyoxylate
pH 8.0, 37C, alanine as amino donor
Mus musculus
1
-
glyoxylate
pH 8.2, 37C, isoenzyme 2, alanine as amino donor
Rattus norvegicus
1.4
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Mus musculus
2.1
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Rattus norvegicus
3
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Canis lupus familiaris
3.9
-
L-alanine
pH 8.2, 37C, isoenzyme 1, glyoxylate as amino acceptor
Canis lupus familiaris
25
-
L-alanine
pH 8.2, 37C, isoenzyme 2, glyoxylate as amino acceptor
Mus musculus
30
-
L-alanine
pH 8.2, 37C, isoenzyme 2, glyoxylate as amino acceptor
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Canis lupus familiaris
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Felis catus
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Mus musculus
38000
-
2 * 38000, isoenzyme 1, SDS-PAGE
Rattus norvegicus
77000
-
-
Canis lupus familiaris
77000
-
-
Felis catus
77000
-
-
Mus musculus
77000
-
isoenzyme 1, gel filtration
Rattus norvegicus
80000
-
sucrose-density-gradient centrifugation
Canis lupus familiaris
80000
-
sucrose-density-gradient centrifugation
Felis catus
80000
-
sucrose-density-gradient centrifugation
Mus musculus
80000
-
peroxisomal and mitochondrial alanine-glyoxylate aminotransferase 1; sucrose-density-gradient centrifugation
Rattus norvegicus
170000
-
isoenzyme 2, gel filtration
Rattus norvegicus
175000
-
-
Canis lupus familiaris
175000
-
liver isoenzyme 2, gel filtration
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-alanine + glyoxylate
Mus musculus
-
pyruvate + glycine
-
Mus musculus
ir
L-alanine + glyoxylate
Rattus norvegicus
-
pyruvate + glycine
-
Rattus norvegicus
ir
L-alanine + glyoxylate
Canis lupus familiaris
-
pyruvate + glycine
-
Canis lupus familiaris
ir
L-alanine + glyoxylate
Felis catus
-
pyruvate + glycine
-
Felis catus
ir
Purification (Commentary) (protein specific)
Commentary
Organism
isoenzyme 1
Canis lupus familiaris
isoenzyme 1
Felis catus
isoenzyme 1 and 2
Mus musculus
isoenzyme 1 and 2
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
liver
-
Canis lupus familiaris
-
liver
-
Felis catus
-
liver
-
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
2.64
-
isoenzyme 2
Canis lupus familiaris
2.93
-
isoenzyme 2
Canis lupus familiaris
2.93
-
-
Rattus norvegicus
21.4
-
isoenzyme 1
Rattus norvegicus
23.2
-
isoenzyme 1
Mus musculus
86.3
-
isoenzyme 1
Felis catus
91
-
isoenzyme 1
Canis lupus familiaris
160
-
isoenzyme 1
Rattus norvegicus
Storage Stability (protein specific)
Storage Stability
Organism
-20C, 50 mM potassium phosphate buffer, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Rattus norvegicus
-20C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Mus musculus
-20C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Canis lupus familiaris
-20C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity
Felis catus
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Mus musculus
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Rattus norvegicus
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Canis lupus familiaris
0-6C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity
Felis catus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
L-alanine + glyoxylate
-
640067
Mus musculus
pyruvate + glycine
-
640067
Mus musculus
ir
L-alanine + glyoxylate
-
640067
Rattus norvegicus
pyruvate + glycine
-
640067
Rattus norvegicus
ir
L-alanine + glyoxylate
-
640067
Canis lupus familiaris
pyruvate + glycine
-
640067
Canis lupus familiaris
ir
L-alanine + glyoxylate
-
640067
Felis catus
pyruvate + glycine
-
640067
Felis catus
ir
L-alanine + glyoxylate
isoenzyme 1
640067
Mus musculus
pyruvate + glycine
-
640067
Mus musculus
ir
L-alanine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
pyruvate + glycine
-
640067
Rattus norvegicus
ir
L-alanine + glyoxylate
isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors
640067
Mus musculus
pyruvate + glycine
-
640067
Mus musculus
ir
L-alanine + glyoxylate
isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors
640067
Rattus norvegicus
pyruvate + glycine
-
640067
Rattus norvegicus
ir
L-alanine + hydroxypyruvate
-
640067
Canis lupus familiaris
pyruvate + L-serine
-
-
-
ir
L-alanine + hydroxypyruvate
-
640067
Felis catus
pyruvate + L-serine
-
-
-
ir
L-alanine + hydroxypyruvate
isoenzyme 1
640067
Mus musculus
pyruvate + L-serine
-
-
-
ir
L-alanine + hydroxypyruvate
isoenzyme 1
640067
Rattus norvegicus
pyruvate + L-serine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1
640067
Mus musculus
pyruvate + L-phenylalanine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1
640067
Rattus norvegicus
pyruvate + L-phenylalanine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1, less effectively acceptor
640067
Canis lupus familiaris
pyruvate + L-phenylalanine
-
-
-
ir
L-alanine + phenylpyruvate
isoenzyme 1, less effectively acceptor
640067
Felis catus
pyruvate + L-phenylalanine
-
-
-
ir
L-asparagine + glyoxylate
isoenzyme 1
640067
Mus musculus
4-amino-2,4-dioxobutanoate + glycine
-
-
-
ir
L-asparagine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
4-amino-2,4-dioxobutanoate + glycine
-
-
-
ir
L-glutamine + glyoxylate
isoenzyme 1
640067
Mus musculus
2-oxoglutaramate + glycine
-
-
-
ir
L-glutamine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
2-oxoglutaramate + glycine
-
-
-
ir
L-histidine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
ir
L-histidine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
ir
L-isoleucine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-methyl-2-oxopropanoate + glycine
-
-
-
ir
L-leucine + glyoxylate
isoenzyme 1
640067
Mus musculus
4-methyl-2-oxopentanoate + glycine
-
-
-
ir
L-leucine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
4-methyl-2-oxopentanoate + glycine
-
-
-
ir
L-methionine + glyoxylate
isoenzyme 1
640067
Mus musculus
4-methylsulfanyl-2-oxobutanoate + glycine
-
-
-
ir
L-methionine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
4-methylsulfanyl-2-oxobutanoate + glycine
-
-
-
ir
L-phenylalanine + glyoxylate
isoenzyme 1
640067
Mus musculus
phenylpyruvate + glycine
-
-
-
ir
L-phenylalanine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
phenylpyruvate + glycine
-
-
-
ir
L-serine + glyoxylate
-
640067
Canis lupus familiaris
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
-
640067
Felis catus
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Mus musculus
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Rattus norvegicus
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Canis lupus familiaris
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
isoenzyme 1
640067
Felis catus
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-tyrosine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
ir
L-tyrosine + glyoxylate
isoenzyme 1
640067
Rattus norvegicus
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
ir
L-valine + glyoxylate
isoenzyme 1
640067
Mus musculus
3-methyl-2-oxobutanoate + glycine
-
-
-
ir
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Mus musculus
?
-
-
-
-
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Rattus norvegicus
?
-
-
-
-
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Canis lupus familiaris
?
-
-
-
-
additional information
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
640067
Felis catus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Canis lupus familiaris
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Felis catus
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Mus musculus
dimer
2 * 38000, isoenzyme 1, SDS-PAGE
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.1
8.4
isoenzyme 2
Mus musculus
8.3
8.6
-
Canis lupus familiaris
8.3
8.6
-
Felis catus
8.3
8.6
-
Mus musculus
8.3
8.6
-
Rattus norvegicus
8.5
8.8
isoenzyme 2
Rattus norvegicus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Mus musculus
isoelectric focusing on a pH 3.5-10 ampholine gradient
-
5.9
Rattus norvegicus
isoelectric focusing on a pH 3.5-10 ampholine gradient
-
6
Other publictions for EC 2.6.1.44
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737777
Fargue
Effects of alanine:glyoxylate ...
Homo sapiens
Biochim. Biophys. Acta
1862
1055-1062
2016
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737947
Abe
Distribution of D-3-aminoisobu ...
Rattus norvegicus
BMC Neurosci.
15
53
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739170
Rodionov
Role of alanine:glyoxylate ami ...
Mus musculus
Nephrol. Dial. Transplant.
29
2035-2042
2014
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722812
Fargue
Four of the most common mutati ...
Homo sapiens
J. Biol. Chem.
288
2475-2484
2013
-
-
1
-
5
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737740
Oppici
Gly161 mutations associated wi ...
Homo sapiens
Biochim. Biophys. Acta
1832
2277-2288
2013
-
1
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739610
Oppici
Crystal structure of the S187F ...
Homo sapiens
Proteins
81
1457-1465
2013
-
-
-
1
1
-
-
2
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
1
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
721240
Kawai
A novel mutation of human live ...
Homo sapiens
Acta Histochem. Cytochem.
45
121-129
2012
-
-
1
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721464
Caplin
Alanine-glyoxylate aminotransf ...
Mus musculus
Arterioscler. Thromb. Vasc. Biol.
32
2892-2900
2012
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722393
Montioli
The N-terminal extension is es ...
Homo sapiens
Int. J. Biochem. Cell Biol.
44
536-546
2012
-
-
1
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
723487
Bhadauria
Alanine: Glyoxylate aminotrans ...
Pyricularia oryzae
Plant Signal. Behav.
7
1206-1208
2012
-
-
1
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
723562
Bhadauria
Peroxisomal alanine: glyoxylat ...
Pyricularia oryzae
PLoS ONE
7
e36266
2012
-
-
1
-
-
-
-
-
3
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
721718
Cellini
Human liver peroxisomal alanin ...
Homo sapiens
Biochim. Biophys. Acta
1814
1577-1584
2011
-
-
1
1
7
-
-
16
1
-
-
-
-
2
-
-
1
-
-
1
-
-
1
1
1
-
-
-
16
-
-
-
1
-
-
-
-
-
1
1
1
7
-
-
-
-
16
1
-
-
-
-
-
-
1
-
1
-
-
1
1
-
-
-
16
-
-
-
-
-
1
1
-
16
16
723614
Ichiyama
Studies on a unique organelle ...
Homo sapiens
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
87
274-286
2011
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701547
Djordjevic
Structural implications of a G ...
Homo sapiens
Acta Crystallogr. Sect. F
66
233-236
2010
-
-
1
1
1
-
1
-
1
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
1
-
-
1
-
-
1
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703680
Kameya
Purification of three aminotra ...
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6 / IAM 12695
FEBS J.
277
1876-1885
2010
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
1
-
-
-
2
-
2
1
4
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
1
-
-
2
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
704697
Rodionov
Human alanine-glyoxylate amino ...
Homo sapiens
J. Biol. Chem.
285
5385-5391
2010
-
-
1
-
-
-
-
-
1
-
1
-
-
3
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706556
Cellini
Molecular defects of the glyci ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
107
2896-2901
2010
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721754
Cellini
Human liver peroxisomal alanin ...
Homo sapiens
Biochimie
92
1801-1811
2010
-
-
1
-
3
1
-
-
1
-
-
-
-
2
-
-
1
-
1
1
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
3
1
-
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
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Molecular insight into the syn ...
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684152
Sakuraba
Structure of an archaeal alani ...
Thermococcus litoralis
Acta Crystallogr. Sect. D
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Bertoldi
Reactions of human liver perox ...
Homo sapiens
Biochim. Biophys. Acta
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3
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Ikeda
Characterization of peroxisoma ...
Homo sapiens
Biol. Pharm. Bull.
31
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2008
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Hopper
In vivo and in vitro examinati ...
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689026
Coulter-Mackie
Partial trypsin digestion as a ...
Homo sapiens
Mol. Genet. Metab.
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368-374
2008
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689893
Cellini
Construction, purification and ...
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Protein Pept. Lett.
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684989
Cellini
Human wild-type alanine:glyoxy ...
Homo sapiens
Biochem. J.
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671871
Han
Evolution of two alanine glyox ...
Aedes aegypti
Biochem. J.
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1
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Han
Crystal structures of Aedes ae ...
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1
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675140
Ricoult
Characterization of alanine am ...
Medicago truncatula
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57
3079-3089
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676030
Coulter-Mackie
Consequences of missense mutat ...
Homo sapiens
Mol. Genet. Metab.
89
349-359
2006
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676835
Salido
Alanine-glyoxylate aminotransf ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
18249-18254
2006
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1
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660780
Kato
Expression of alanine:glyoxyla ...
Saccharomyces cerevisiae
Appl. Microbiol. Biotechnol.
71
46-52
2005
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1
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1
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661283
Meyer
Crystal structure and confirma ...
Saccharomyces cerevisiae
Biochimie
87
1041-1047
2005
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1
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1
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1
1
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662884
Coulter-Mackie
The major allele of the alanin ...
Homo sapiens
Mol. Genet. Metab.
86
172-178
2005
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5
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663312
Coulter-Mackie
Overexpression of human alanin ...
Homo sapiens
Protein Expr. Purif.
41
18-26
2005
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5
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1
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5
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1
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663368
Han
Crystal structure of an alanin ...
Anabaena sp.
Proteins Struct. Funct. Bioinform.
58
971-975
2005
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1
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1
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1
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1
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1
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671206
Koul
Cellular transfection to deliv ...
Homo sapiens
Am. J. Nephrol.
25
176-182
2005
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1
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1
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1
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1
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1
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674458
Huber
Peroxisomal import of human al ...
Homo sapiens
J. Biol. Chem.
280
27111-27120
2005
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1
1
2
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1
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1
1
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662014
Sakuraba
Novel archaeal alanine:glyoxyl ...
Thermococcus litoralis
J. Bacteriol.
186
5513-5518
2004
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2
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1
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2
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1
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3
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3
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1
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1
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2
2
1
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2
-
1
-
-
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-
-
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663449
Schlosser
Alanine:glyoxylate aminotransf ...
Saccharomyces cerevisiae
Yeast
21
63-73
2004
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-
-
-
1
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-
-
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4
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1
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1
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640086
Danpure
Alanine:glyoxylate aminotransf ...
Homo sapiens
Biochim. Biophys. Acta
1647
70-75
2003
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1
1
1
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1
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1
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1
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1
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1
1
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1
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1
1
1
1
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1
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1
1
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1
-
1
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1
1
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640087
Santana
Primary hyperoxaluria type 1 i ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
100
7277-7282
2003
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1
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1
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1
1
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1
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2
1
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1
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1
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1
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640088
Zhang
Crystal structure of alanine:g ...
Homo sapiens
J. Mol. Biol.
331
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662732
Nishijima
Hepatic alanine-glyoxylate ami ...
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J. Urol.
169
683-686
2003
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1
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663117
Liepman
Alanine aminotransferase homol ...
Arabidopsis thaliana
Plant Physiol.
131
215-227
2003
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1
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Han
Comparative characterization o ...
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Liepman
Peroxisomal alanine: glyoxylat ...
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Crystallization and preliminar ...
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1
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-
-
-
-
-
-
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-
-
-
-
-
640080
Holbrook
Molecular adaptation of alanin ...
Ateles paniscus, Callimico goeldii, Callithrix jacchus, Cercopithecus diana, Cheirogaleus medius, Eulemur fulvus, Gorilla gorilla, Homo sapiens, Hylobates lar, Leontopithecus rosalia, Loris tardigradus, Macaca fuscata, Macaca nigra, Mico argentatus, Nycticebus pygmaeus, Pan troglodytes, Papio anubis, Pithecia pithecia, Pongo pygmaeus, Saguinus oedipus, Saimiri sciureus
Mol. Biol. Evol.
17
387-400
2000
-
-
12
-
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-
-
21
-
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21
-
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12
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21
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
640081
Lumb
Functional synergism between t ...
Homo sapiens
J. Biol. Chem.
275
36415-36422
2000
-
1
1
-
-
-
-
4
1
-
1
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-
1
-
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1
-
-
1
1
-
-
1
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-
-
-
-
1
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-
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-
-
1
1
-
-
-
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-
-
4
1
-
1
-
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-
-
1
-
1
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640082
Oda
Mitochondrial targeting signal ...
Rattus norvegicus
J. Biochem.
127
665-671
2000
-
-
1
-
-
-
-
-
4
-
1
-
-
2
-
-
1
-
-
2
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-
-
1
1
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-
-
-
-
-
-
-
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1
-
-
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-
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-
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4
-
1
-
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1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640079
Rumsby
-
A semiautomated alanine:glyoxy ...
Homo sapiens
Ann. Clin. Biochem.
34
400-404
1997
-
1
-
-
-
-
-
2
1
-
-
1
-
1
-
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-
-
1
-
-
1
-
-
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-
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-
1
1
-
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1
-
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-
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2
1
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-
1
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-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
640077
Ishikawa
Pyridoxal 5'-phosphate binding ...
Rattus norvegicus
J. Biochem.
119
970-978
1996
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
1
-
-
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
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-
1
-
-
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1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640078
Leiper
Inhibition of alanine:glyoxyla ...
Homo sapiens
J. Cell. Biol.
135
939-951
1996
-
1
1
-
-
-
-
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1
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2
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-
1
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1
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1
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1
1
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1
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2
-
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-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640076
Horvath
Aminooxy acetic acid: a select ...
Homo sapiens
Clin. Chim. Acta
243
105-114
1995
-
1
-
-
-
-
1
-
1
-
-
-
-
1
-
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-
1
-
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640075
Danpure
Cytosolic compartmentalization ...
Homo sapiens
J. Inherit. Metab. Dis.
17
27-40
1994
-
1
1
-
-
-
-
-
2
-
1
1
-
1
-
-
1
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
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-
1
1
-
-
-
-
-
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-
-
2
-
1
1
-
-
-
1
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640074
Sakuraba
Purification and characterizat ...
Anas platyrhynchos domestica, Anser anser domesticus, Columba livia, Gallus gallus, Melopsittacus undulatus, Padda oryzivora, Passer montanus saturatus, Phasianus versicolor, Serinus canaria, Uroloncha striata domestica
Arch. Biochem. Biophys.
286
453-460
1991
-
-
-
-
-
1
-
-
11
-
7
2
-
16
-
-
2
-
-
11
1
4
2
4
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
11
-
7
2
-
-
-
2
-
11
1
4
2
4
-
-
-
-
2
-
-
-
-
-
-
-
-
-
640073
Kobayashi
Identity of alanine:glyoxylate ...
Rattus norvegicus
Biochimie
71
471-475
1989
-
-
-
-
-
-
-
-
4
-
3
-
-
2
-
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-
2
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2
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-
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-
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-
1
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-
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-
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-
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4
-
3
-
-
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
640072
Okuno
Alanine:glyoxylate aminotransf ...
Suncus murinus
Comp. Biochem. Physiol. B
90
773-778
1988
-
-
-
-
-
-
1
3
-
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1
-
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3
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2
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1
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1
1
3
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640071
Takada
Characteristics of alanine: gl ...
Saccharomyces cerevisiae
Biochem. J.
231
157-163
1985
-
-
-
-
-
-
4
2
-
-
2
1
-
3
-
-
1
-
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-
1
2
3
1
-
-
-
-
-
1
-
-
1
-
1
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-
-
-
1
-
-
-
-
4
-
2
-
-
2
1
-
-
-
1
-
-
1
2
3
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
640070
Noguchi
Enzymatic and immunological co ...
Caranx chrysos, Sardinops sp., Scomberomorus sp., Sebastes carnatus
Comp. Biochem. Physiol. B
77
279-283
1984
-
-
-
-
-
-
-
-
-
-
1
1
-
4
-
-
4
-
-
1
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3
1
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-
-
-
-
-
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-
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-
-
-
-
-
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-
-
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-
1
1
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4
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640069
Nakamura
Serine: glyoxylate, alanine:gl ...
Spinacia oleracea
J. Biol. Chem.
258
7631-7638
1983
-
-
-
-
-
-
3
3
1
-
-
1
-
1
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-
-
-
-
1
-
1
2
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
2
3
1
-
-
1
-
-
-
-
-
1
-
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640068
Okuno
Co-purification of alanine-gly ...
Rattus norvegicus
Biochim. Biophys. Acta
715
97-104
1982
-
-
-
-
-
-
-
8
-
-
5
1
-
2
-
-
1
-
-
3
1
3
8
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
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8
-
-
5
1
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-
-
1
-
3
1
3
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640067
Noguchi
Characteristics of hepatic ala ...
Canis lupus familiaris, Felis catus, Mus musculus, Rattus norvegicus
Biochem. J.
169
113-122
1978
4
-
-
-
-
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10
12
5
-
15
4
-
8
-
-
4
-
-
8
8
8
44
4
1
-
-
-
-
6
-
-
-
-
2
-
4
-
-
-
-
-
-
-
10
-
12
5
-
15
4
-
-
-
4
-
8
8
8
44
4
-
-
-
-
6
-
-
2
-
-
-
-
-
-
636593
Koide
-
L-alanine-alpha-keto acid amin ...
Pseudomonas sp.
Agric. Biol. Chem.
41
781-784
1977
-
-
-
-
-
-
-
-
-
-
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1
-
1
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-
1
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1
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1
-
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-
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-
1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640065
Rowsell
The subcellular distribution o ...
Rattus norvegicus
Biochem. J.
127
155-156
1972
-
-
-
-
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1
2
3
-
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2
-
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-
-
-
2
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-
-
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-
-
2
1
-
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-
-
-
-
-
-
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-
-
-
-
1
-
2
3
-
-
-
-
-
-
-
-
2
-
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-
-
-
-
-
-
2
1
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-
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-