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Literature summary for 2.6.1.43 extracted from

  • Sagar, R.; Salotra, P.; Bhatnagar, R.; Datta, K.
    L-alanine: 4,5-dioxovalerate transaminase in Leishmania donovani that differs from mammalian enzyme (1995), Microbiol. Res., 150, 419-423.
    View publication on PubMed
Search for more literature for 2.6.1.43

Application

Application Comment Organism
medicine immunological difference between the enzyme from mammalian source and this enzyme presents a potential target for chemotherapy, development of treatment for Leishmaniasis, a major parasitic disease in humans and opportunistic infections in patients with AIDS, an inhibitor specific for the leishmanial enzyme may be used as a therapeutic agent Leishmania donovani

Inhibitors

Inhibitors Comment Organism Structure
hemin
-
 Leishmania donovani
methylglyoxal
-
 Leishmania donovani

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.44
-
 4,5-Dioxopentanoate pH 7.0, 65°C Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + 4,5-dioxopentanoate Leishmania donovani first committed step in heme synthesis 5-aminolevulinate + pyruvate
-
 ir

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
 AG83, WHO nomenclature MHOM/IN/83/AG83, promastigote form
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-alanine + 4,5-dioxopentanoate 65.6% of the activity with L-alanine Leishmania donovani 5-aminolevulinate + malonic semialdehyde
-
 ir
glycine + 4,5-dioxopentanoate 81.2% of the activity with L-alanine Leishmania donovani 5-aminolevulinate + glyoxylate
-
 ir
L-alanine + 4,5-dioxopentanoate
-
 Leishmania donovani 5-aminolevulinate + pyruvate
-
 ir
L-alanine + 4,5-dioxopentanoate first committed step in heme synthesis Leishmania donovani 5-aminolevulinate + pyruvate
-
 ir
L-glutamate + 4,5-dioxopentanoate 43.8% of the activity with L-alanine Leishmania donovani 5-aminolevulinate + 2-oxoglutarate
-
 ir
L-phenylalanine + 4,5-dioxopentanoate 90.6% of the activity with L-alanine Leishmania donovani phenylpyruvate + 5-aminolevulinate
-
 ir
additional information cysteine is no substrate Leishmania donovani ?
-
 ?

Synonyms

Synonyms Comment Organism
EC 2.6.1.40 dimethylarginine-pyruvate aminotransferase and D-3-aminoisobutyrate pyruvate aminotransferase activities resides in the same protein Leishmania donovani
EC 2.6.1.44 alanine-glyoxylate transaminase and aminolevulinate transaminase activities reside in the same protein Leishmania donovani

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
65
-
-
 Leishmania donovani