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Literature summary for 2.6.1.43 extracted from

  • Bajkowski, A.S.; Friedmann, H.C.
    delta-Aminolevulinic acid formation. Purification and properties of alanine:4,5-dioxovalerate, aminotransferase and isolation of 4,5-dioxovalerate from Clostridium tetanomorphum (1982), J. Biol. Chem., 257, 2207-2211.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
Clostridium tetanomorphum
amino-oxyacetic acid
-
Clostridium tetanomorphum
diacetyl
-
Clostridium tetanomorphum
Glyoxal
-
Clostridium tetanomorphum
glyoxylic acid
-
Clostridium tetanomorphum
methylglyoxal
-
Clostridium tetanomorphum
oxaloacetic acid
-
Clostridium tetanomorphum
pyruvate
-
Clostridium tetanomorphum
succinate semialdehyde
-
Clostridium tetanomorphum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.26
-
4,5-Dioxopentanoate pH 6.9, 37°C Clostridium tetanomorphum
1.96
-
L-alanine pH 6.9, 37°C Clostridium tetanomorphum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55500
-
2 * 55500, SDS-PAGE Clostridium tetanomorphum
72000
-
sedimentation equilibrium centrifugation, potassium phosphate buffer containing 4 M NaCl Clostridium tetanomorphum
78000
-
sedimentation equilibrium centrifugation, potassium phosphate buffer Clostridium tetanomorphum
82000
-
gel filtration Clostridium tetanomorphum
111000
-
gel filtration Clostridium tetanomorphum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + 4,5-dioxopentanoate Clostridium tetanomorphum
-
5-aminolevulinate + pyruvate
-
ir

Organism

Organism UniProt Comment Textmining
Clostridium tetanomorphum
-
ATCC 15920
-

Purification (Commentary)

Purification (Comment) Organism
-
Clostridium tetanomorphum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.68
-
-
Clostridium tetanomorphum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + 4,5-dioxopentanoate
-
Clostridium tetanomorphum 5-aminolevulinate + pyruvate
-
ir
L-aspartate + 4,5-dioxopentanoate 67% of the activity with L-alanine Clostridium tetanomorphum 5-aminolevulinate + oxaloacetate
-
ir
L-glutamate + 4,5-dioxopentanoate 96% of the activity with L-alanine Clostridium tetanomorphum 5-aminolevulinate + 2-oxoglutarate
-
ir
L-histidine + 4,5-dioxopentanoate 74% of the activity with L-alanine Clostridium tetanomorphum 5-aminolevulinate + 3-(1H-imidazol-4-yl)-2-oxopropanoate
-
ir
L-phenylalanine + 4,5-dioxopentanoate 71% of the activity with L-alanine Clostridium tetanomorphum phenylpyruvate + 5-aminolevulinate
-
ir

Subunits

Subunits Comment Organism
dimer 2 * 55500, SDS-PAGE Clostridium tetanomorphum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Clostridium tetanomorphum