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Literature summary for 2.6.1.39 extracted from
- alpha-Aminoadipate aminotransferase and kynurenine aminotransferase. Purification, characterization, and further evidence for identity (1977), J. Biol. Chem., 252, 4591-4599.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-serine-O-sulfate | - |
Rattus norvegicus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45500 | - |
2 * 45500, SDS-PAGE | Rattus norvegicus |
| 82100 | - |
gel filtration | Rattus norvegicus |
| 85000 | - |
sucrose density gradient centrifugation | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-aminoadipate + 2-oxoglutarate | Rattus norvegicus | lysine catabolic pathway | 2-oxoadipate + L-glutamate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
albino rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.65 | - |
kynurenine aminotransferase activity | Rattus norvegicus |
| 26.1 | - |
alpha-aminoadipate aminotransferase activity | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-aminoadipate + 2-oxoglutarate | - |
Rattus norvegicus | 2-oxoadipate + L-glutamate | - |
r | |
| L-2-aminoadipate + 2-oxoglutarate | lysine catabolic pathway | Rattus norvegicus | 2-oxoadipate + L-glutamate | - |
r | |
| additional information | 2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 45500, SDS-PAGE | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | 70 | inactivation is initiated at 60°C and is near completion at 70°C | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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