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Literature summary for 2.6.1.39 extracted from
- Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney (1995), J. Biol. Chem., 270, 29330-29335.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | L-2-aminoadipate, the substrate for AadAT, is a well known astroglial-specific toxin, knowledge of the cerebral disposition of this compound is instrumental for the elucidation of its mechanism of toxicity and possible relevance in pathology | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| kynurenine/alpha-aminoadipate aminotransferase cDNA cloned and expressed in HEK-293 cells | Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
2 * 45000, SDS-PAGE | Rattus norvegicus |
| 47789 | - |
2 * 47789, amino acid residues | Rattus norvegicus |
| 100000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-aminoadipate + 2-oxoglutarate | Rattus norvegicus | lysine catabolic pathway | 2-oxoadipate + L-glutamate | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q64602 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.56 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kynurenine + 2-oxoglutarate | - |
Rattus norvegicus | kynurenic acid + L-glutamate | - |
ir | |
| L-2-aminoadipate + 2-oxoglutarate | - |
Rattus norvegicus | 2-oxoadipate + L-glutamate | - |
r | |
| L-2-aminoadipate + 2-oxoglutarate | lysine catabolic pathway | Rattus norvegicus | 2-oxoadipate + L-glutamate | - |
r | |
| additional information | 2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 45000, SDS-PAGE | Rattus norvegicus |
| dimer | 2 * 47789, amino acid residues | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AadAT | - |
Rattus norvegicus |
| kynurenine/alpha-aminoadipate aminotransferase | - |
Rattus norvegicus |
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