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Literature summary for 2.6.1.38 extracted from

  • Moriya, Y.; Yamada, T.; Okuda, S.; Nakagawa, Z.; Kotera, M.; Tokimatsu, T.; Kanehisa, M.; Goto, S.
    Identification of enzyme genes using chemical structure alignments of substrate-product pairs (2016), J. Chem. Inf. Model., 56, 510-516 .
    View publication on PubMed
Search for more literature for 2.6.1.38

Organism

Organism UniProt Comment Textmining
Caldanaerobacter subterraneus subsp. tengcongensis Q8R5Q4 i.e. Thermoanaerobacter tengcongensis
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Caldanaerobacter subterraneus subsp. tengcongensis DSM 15242 Q8R5Q4 i.e. Thermoanaerobacter tengcongensis
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Caldanaerobacter subterraneus subsp. tengcongensis JCM 11007 Q8R5Q4 i.e. Thermoanaerobacter tengcongensis
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Caldanaerobacter subterraneus subsp. tengcongensis NBRC 100824 Q8R5Q4 i.e. Thermoanaerobacter tengcongensis
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Synonyms

Synonyms Comment Organism
HisC
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 Caldanaerobacter subterraneus subsp. tengcongensis
histidine transaminase
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 Caldanaerobacter subterraneus subsp. tengcongensis
More cf. EC 2.6.1.9 Caldanaerobacter subterraneus subsp. tengcongensis
TTE2137
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 Caldanaerobacter subterraneus subsp. tengcongensis

General Information

General Information Comment Organism
additional information development and evaluation of a method for the prediction of possible genes of orphan enzyme reactions where any associated gene sequences are not determined to date. The candidate enzyme gene of a reaction is detected using the chemical structures of the substrate-product pair (reactant pair). The proposed method is based on a search for similar reactant pairs in a reference database (KEGG database) and offers orthologeous groups that possibly mediate the given reaction. One example is the histidine transaminase (R01161, EC 2.6.1.38), which transfers an amino group from histidine to glutamate. For the query consisting of histidine and imidazol-5-pyruvate (RP01339 in the RPAIR database), K00817 is predicted by the method with the highest score (0.971). The function of this KO entry is the transfer of an amino group from phenylalanine, tyrosine, and histidinol phosphate (histidinol-phosphate transaminase, EC 2.6.1.9), which are structurally similar to histidine, to glutamate. In addition, this KO entry contains the enzyme gene sequence tte:TTE2137 of Thermoanaerobacter tengcongensis, for which a histidine transaminase activity has been detected in the heterologous expression study Caldanaerobacter subterraneus subsp. tengcongensis