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Literature summary for 2.6.1.23 extracted from

  • Goldstone, A.; Adams, E.
    Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase of rat liver (1962), J. Biol. Chem., 237, 3476-3485.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hydroxylamine 70% inhibition at 1 mM Rattus norvegicus
L-glutarate 63% inhibition at 0.5 mM Rattus norvegicus
Maleate 65% inhibition at 5 mM Rattus norvegicus
N-ethylmaleimide 50% inhibition at 5 mM Rattus norvegicus
p-chloromercuribenzoate 77% inhibition at 0.5 mM Rattus norvegicus
phenylhydrazine 84% inhibition at 1 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.41
-
2-oxoglutarate pH 8.1, 37°C Rattus norvegicus
33
-
L-glutamate pH 8.1, 37°C Rattus norvegicus
240
-
L-erythro-4-hydroxyglutamate pH 8.1, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxy-L-glutamate + oxo acid Rattus norvegicus metabolism of 4-hydroxy-L-glutamate in rat liver 4-hydroxy-2-oxoglutarate + L-glutamate
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.49
-
partially purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxy-L-glutamate + 2-oxoglutarate enzyme utilises erythro-L-4-hydroxyglutamate and threo-L-4-hydroxyglutamate to the same extent, but no D-isomers Rattus norvegicus 4-hydroxy-2-oxoglutarate + L-glutamate
-
r
4-hydroxy-L-glutamate + oxaloacetate
-
Rattus norvegicus 4-hydroxy-2-oxoglutarate + L-aspartate
-
r
4-hydroxy-L-glutamate + oxo acid metabolism of 4-hydroxy-L-glutamate in rat liver Rattus norvegicus 4-hydroxy-2-oxoglutarate + L-glutamate
-
r
L-erythro-4-hydroxyglutamate + 2-oxoglutarate
-
Rattus norvegicus D-4-hydroxy-2-oxoglutarate + L-glutamate
-
?
additional information substrate stereospecificity Rattus norvegicus ?
-
?
additional information pyruvate is a poor substrate Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
More may be identical with EC 2.6.1.1 aspartate transaminase Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
with erythro-L-hydroxyglutamic acid Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.7 9.5 pH 6.7: about 45% of activity maximum, pH 9.5: about 55% of activity maximum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
additional information no cofactor requirement Rattus norvegicus