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Literature summary for 2.6.1.21 extracted from

  • Martinez-Carrion, M.; Jenkins, W.T.
    D-Alanine-D-glutamate transaminase. II. Inhibitors and the mechanism of transamination of D-amino acids (1965), J. Biol. Chem., 240, 3547-3552.
    View publication on PubMed
Search for more literature for 2.6.1.21

Inhibitors

Inhibitors Comment Organism Structure
aminooxyacetic acid 0.0001 mM, 50% inhibition Bacillus subtilis
cysteine inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate Bacillus subtilis
D-2-aminobutanoate inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak Bacillus subtilis
D-asparagine inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak Bacillus subtilis
D-Aspartate inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak Bacillus subtilis
D-cysteine 0.1 mM, 60% inhibition Bacillus subtilis
D-glutamate competitive to D-alanine, noncompetitive to 2-oxoglutarate Bacillus subtilis
D-methionine inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak Bacillus subtilis
D-oxamycin 0.000025 mM, 50% inhibition Bacillus subtilis
D-serine inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate Bacillus subtilis
DL-alpha-Methylserine inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak Bacillus subtilis
hydroxylamine 0.1 mM, 91% inhibition Bacillus subtilis
L-cysteine 2 mM, 49% inhibition Bacillus subtilis
L-oxamycin 0.001 mM, 50% inhibition Bacillus subtilis
L-serine 10 mM, 22% inhibition Bacillus subtilis
Maleate 12 mM, 30% inhibition at pH 7.1, no inhibition at pH 8.3 Bacillus subtilis
additional information not inhibited by malic acid, KCN, iodoacetic acid, p-chloromercuribenzoate and HgCl2 Bacillus subtilis
oxamycin D-isomer by a factor of 40 more inhibitory than L-isomer Bacillus subtilis
succinate 12 mM, 18% inhibition at pH 7.1, no inhibition at pH 8.3 Bacillus subtilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4
-
 2-oxoglutarate cosubstrate D-alanine Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + pyruvate
-
 Bacillus subtilis pyruvate + D-alanine
-
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