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Literature summary for 2.6.1.19 extracted from

  • Han, Y.; Cao, D.; Li, X.; Zhang, R.; Yu, F.; Ren, Y.; An, L.
    Attenuation of gamma-aminobutyric acid (GABA) transaminase activity contributes to GABA increase in the cerebral cortex of mice exposed to beta-cypermethrin (2014), Hum. Exp. Toxicol., 33, 317-324.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
beta-cypermethrin GABA transaminase activity detected is significantly decreased in the cerebral cortex of mice 2 h after beta-cypermethrin administration. beta-Cypermethrin (80 mg/kg) significantly increases GABA levels in the cerebral cortex of mice, at both 2 and 4 h after treatment, compared with the control. The number of positive granules is increased in the cerebral cortex of mice 4 h after exposure to 80 mg/kg beta-cypermethrin. No significant changes are found in glutamate decarboxylase activity, or the expression of GABA transaminase protein and GABAB receptors mRNA, in the cerebral cortex of mice, except that 80 mg/kg beta-cypermethrin causes a significant decrease in GABAA receptors mRNA expression 4 h after administration Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P61922
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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cerebral cortex
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Mus musculus
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