Literature summary for 2.6.1.19 extracted from

Mathew, B.; Ahsan, M.
Molecular recognisation of 3a, 4-dihydro-3-H-indeno [1, 2-C] pyrazole-2-carboxamide/carbothioamide anticonvulsant analogues towards GABA-aminotransferase - an in silico approach (2014), Cent. Nerv. Syst. Agents Med. Chem., 14, 39-42.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-(4-bromophenyl)-3-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide	molecular docking to propose the binding interaction with a three-dimensional structural model of the gamma-aminobutyric acid amino transferase. The compound successfully binds to the active pocket of the enzyme with good predicted affinities	Sus scrofa
N-(4-bromophenyl)-3-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide	molecular docking to propose the binding interaction with a three-dimensional structural model of the gamma-aminobutyric acid amino transferase. The compound successfully binds to the active pocket of the enzyme with good predicted affinities	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	P80147	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.086	-	predicted value, pH not specified in the publication, temperature not specified in the publication	Sus scrofa	N-(4-bromophenyl)-3-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide
0.149	-	predicted value, pH not specified in the publication, temperature not specified in the publication	Sus scrofa	N-(4-bromophenyl)-3-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide

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Release 2023.1 (January 2023)