Literature summary for 2.6.1.19 extracted from

Fu, M.; Nikolic, D.; Van Breemen, R.B.; Silverman, R.B.
Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid (1999), J. Am. Chem. Soc., 121, 7751-7759.

No PubMed abstract available

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Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid	mechanism-based inactivator, reacts via aromatization mechanism	Sus scrofa
vigabatrin	mechanism	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid + 2-oxoglutarate	mechanism-based inactivator that partly undergoes inactivation	Sus scrofa	4-oxo-4,5-dihydro-2-thiophenecarboxylic acid + L-glutamate	-	?

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Release 2023.1 (January 2023)