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Literature summary for 2.6.1.19 extracted from

  • Maître, M.; Ciesielski, L.; Cash, C.; Mandel, P.
    Purification and studies on some properties of the 4-aminobutyrate: 2-oxoglutarate transaminase from rat brain (1975), Eur. J. Biochem., 52, 157-169.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
Rattus norvegicus
Succinic semialdehyde substrate inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic study Rattus norvegicus
additional information
-
additional information pH-dependence of kinetic data Rattus norvegicus
4
-
4-aminobutanoate 38°C, pH 8.5 Rattus norvegicus
5.5
-
2-oxoglutarate 38°C, pH 8.5 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
2 * 57000, SDS-PAGE with or without DTT or urea Rattus norvegicus
103000
-
PAGE Rattus norvegicus
105000
-
gel filtration Rattus norvegicus
107000
-
calculated from amino acid composition Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10
-
38°C, pH 8.5 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
Rattus norvegicus 4-oxobutanoate + L-glutamate
-
r

Subunits

Subunits Comment Organism
dimer 2 * 57000, SDS-PAGE with or without DTT or urea Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
-
Rattus norvegicus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
30 55 about half-maximal activity at 30°C and 55°C Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
35
-
t1/2: 3 h Rattus norvegicus
50
-
3 h, 80% loss of activity Rattus norvegicus
55
-
3 h, inactivation Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
pI: 6.8 Rattus norvegicus
8.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7.4 9 about half-maximal activity at pH 7.4 and about 90% of maximal activity at pH 9 Rattus norvegicus
8 9.2 about 50% of maximal activity at pH 9.2 Rattus norvegicus
8 9.2 about half-maximal activity at pH 8 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00018
-
2-oxoglutarate 38°C, pH 8.5 Rattus norvegicus
0.0066
-
Succinic semialdehyde 38°C, pH 8.5 Rattus norvegicus