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Literature summary for 2.6.1.16 extracted from

  • Pawlak, D.; Stolarska, M.; Wojciechowski, M.; Andruszkiewicz, R.
    Synthesis, anticandidal activity of N(3)-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives - novel inhibitors of glucosamine-6-phosphate synthase (2015), Eur. J. Med. Chem., 90, 577-582.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressiuon in Escherichia coli Candida albicans

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking of inhibitors methyl (2E)-4-([(2S)-2,3-diamino-3-oxopropyl]amino)-4-oxobut-2-enoate and methyl (2E)-4-([(2S)-2-amino-3-(methylamino)-3-oxopropyl]amino)-4-oxobut-2-enoate Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
methyl (2E)-4-([(2S)-2,3-diamino-3-oxopropyl]amino)-4-oxobut-2-enoate
-
 Candida albicans
methyl (2E)-4-([(2S)-2-amino-3-(methylamino)-3-oxopropyl]amino)-4-oxobut-2-enoate
-
 Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.081
-
 pH 7.0, 37°C Candida albicans methyl (2E)-4-([(2S)-2,3-diamino-3-oxopropyl]amino)-4-oxobut-2-enoate
0.127
-
 pH 7.0, 37°C Candida albicans methyl (2E)-4-([(2S)-2-amino-3-(methylamino)-3-oxopropyl]amino)-4-oxobut-2-enoate