Literature summary for 2.6.1.16 extracted from

Pawlak, D.; Schielmann, M.; Wojciechowski, M.; Andruszkiewicz, R.
Synthesis and biological activity of novel ester derivatives of N(3)-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase (2016), Bioorg. Med. Chem. Lett., 26, 3586-3589.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-methyl 8-(2-oxopropyl) (2E,7S)-7-amino-4-oxooct-2-enedioate	ester derivative of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid, potent inhibitory activity against fungal glucosamine-6-phosphate synthase, good antifungal activity against Candida albicans	Candida albicans
1-methyl 8-[(2R)-3-oxobutan-2-yl] (2E,7S)-7-amino-4-oxooct-2-enedioate	ester derivative of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid, potent inhibitory activity against fungal glucosamine-6-phosphate synthase, good antifungal activity against Candida albicans	Candida albicans
8-(3,3-dimethyl-2-oxobutyl) 1-methyl (2E,7S)-7-amino-4-oxooct-2-enedioate	ester derivative of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid, potent inhibitory activity against fungal glucosamine-6-phosphate synthase, good antifungal activity against Candida albicans	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Candida albicans ATCC 10231	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0049	-	pH not specified in the publication, temperature not specified in the publication	Candida albicans	1-methyl 8-[(2R)-3-oxobutan-2-yl] (2E,7S)-7-amino-4-oxooct-2-enedioate
0.0051	-	pH not specified in the publication, temperature not specified in the publication	Candida albicans	1-methyl 8-(2-oxopropyl) (2E,7S)-7-amino-4-oxooct-2-enedioate
0.0052	-	pH not specified in the publication, temperature not specified in the publication	Candida albicans	8-(3,3-dimethyl-2-oxobutyl) 1-methyl (2E,7S)-7-amino-4-oxooct-2-enedioate

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Release 2023.1 (January 2023)