Literature summary for 2.6.1.16 extracted from

Manzari, B.; Kudlow, J.E.; Fardin, P.; Merello, E.; Ottaviano, C.; Puppo, M.; Eva, A.; Varesio, L.
Induction of macrophage glutamine: fructose-6-phosphate amidotransferase expression by hypoxia and by picolinic acid (2007), Int. J. Immunopathol. Pharmacol., 20, 47-58.

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Activating Compound

Activating Compound	Comment	Organism	Structure
desferrioxamine	0.2 mM	Mus musculus
desferrioxamine	activation of gene expression via iron chelation	Mus musculus
Picolinic acid	2 mM	Mus musculus
Picolinic acid	activation of gene expression via iron chelation	Mus musculus

Application

Application	Comment	Organism
medicine	hypoxia induces gene expression in phagocyte	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ANA-1 cell	-	Mus musculus	-
phagocyte	mononuclear phagocyte, constitutive expression of glutamine:fructose 6-phosphate amidotransferase mRNA and protein. Induction of expression by picolinic acid, hypoxia and desferrioxamine	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamine + D-fructose 6-phosphate	-	Mus musculus	L-glutamate + D-glucosamine 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
GFAT	-	Mus musculus
glutamine: fructose-6-phosphate amidotransferase	-	Mus musculus

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Release 2023.1 (January 2023)