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Literature summary for 2.6.1.16 extracted from

  • Wojciechowski, M.; Milewski, S.; Mazerski, J.; Borowski, E.
    Glucosamine-6-phosphate synthase, a novel target for antifungal agents. Molecular modelling studies in drug design (2005), Acta Biochim. Pol., 52, 647-653.
    View publication on PubMed
Search for more literature for 2.6.1.16

Application

Application Comment Organism
medicine target for antifungal agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-amino-2-deoxy-D-glucitol-6-phosphate inhibitor of the sugar isomerising domain Homo sapiens
2-amino-2-deoxy-D-mannitol-6-phosphate exhibits stronger affinity for the sugar-binding site of GlcN-6-P synthase than 2-amino-2-deoxy-D-glucitol-6-phosphate Homo sapiens
6-diazo-5-oxo-L-norleucine inhibitor of the glutamine binding site Homo sapiens
anticapsin inhibitor of the glutamine binding site Homo sapiens
arabinose oxime 5-phosphate inhibitor of the sugar isomerising domain Homo sapiens
N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid acts as active-site-directed inactivator blocking the N-terminal, glutamine-binding domain of the enzyme; inhibitor of the glutamine binding site Homo sapiens
N3-bromoacetyl-L-2,3-diaminopropanoic acid inhibitor of the glutamine binding site Homo sapiens
N3-L-trans-epoxysuccinamoyl-L-2,3-diaminopropanoic acid inhibitor of the glutamine binding site Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + D-fructose 6-phosphate
-
 Homo sapiens L-glutamate + D-glucosamine 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GlcN-6-P synthase
-
 Homo sapiens
glucosamine-6-phosphate synthase
-
 Homo sapiens
L-glutamine: L-fructose-6-phosphate amidotransferase
-
 Homo sapiens